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Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

Author

Listed:
  • Djahida Bouskra

    (Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS, URA1961,)

  • Christophe Brézillon

    (Institut Pasteur, Laboratoire des Bactéries Pathogènes Entériques,)

  • Marion Bérard

    (Institut Pasteur, Animalerie Centrale)

  • Catherine Werts

    (Institut Pasteur, Group of Biology and Genetics of the Bacterial Cell Wall, 25 rue du Dr Roux, Paris 75724, France
    INSERM, Group AVENIR, Paris 75015, France)

  • Rosa Varona

    (Centro Nacional de Biotecnologia/CSIC, UAM Campus Cantoblanco)

  • Ivo Gomperts Boneca

    (Institut Pasteur, Group of Biology and Genetics of the Bacterial Cell Wall, 25 rue du Dr Roux, Paris 75724, France
    INSERM, Group AVENIR, Paris 75015, France)

  • Gérard Eberl

    (Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS, URA1961,)

Abstract

ILF preservation Isolated lymphoid follicles (ILFs) are areas of specialized lymphoid tissue found in the lining of the small intestine where they are involved in protecting the host from invading pathogens. A new study of the composition of ILFs and the factors required for their formation has found that they are induced in the mouse small intestine by the presence of peptidoglycan from Gram-negative bacteria via recognition by the NOD1 innate receptor in epithelia cells. ILFs range from clusters of a few B cells to well-organized lymphoid nodules. Once established, the ILFs exert control over the make-up of the bacterial community. This rare example of microbe-induced tissue genesis in mammals demonstrates how a constructive 'dialogue' between bacteria and host can contribute to efficient digestion and protection from intestinal pathogens.

Suggested Citation

  • Djahida Bouskra & Christophe Brézillon & Marion Bérard & Catherine Werts & Rosa Varona & Ivo Gomperts Boneca & Gérard Eberl, 2008. "Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis," Nature, Nature, vol. 456(7221), pages 507-510, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7221:d:10.1038_nature07450
    DOI: 10.1038/nature07450
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    Cited by:

    1. Hung-Wei Cheng & Urs Mörbe & Mechthild Lütge & Céline Engetschwiler & Lucas Onder & Mario Novkovic & Cristina Gil-Cruz & Christian Perez-Shibayama & Thomas Hehlgans & Elke Scandella & Burkhard Ludewig, 2022. "Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Kaifan Bao & Xiaoqun Gu & Yajun Song & Yijing Zhou & Yanyan Chen & Xi Yu & Weiyuan Yuan & Liyun Shi & Jie Zheng & Min Hong, 2024. "TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Connor Sharp & Kevin R. Foster, 2022. "Host control and the evolution of cooperation in host microbiomes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Kerstin Thriene & Karin B. Michels, 2023. "Human Gut Microbiota Plasticity throughout the Life Course," IJERPH, MDPI, vol. 20(2), pages 1-14, January.

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