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The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila

Author

Listed:
  • Hsiao-Lan Liang

    (New York University, 100 Washington Square East, New York, New York 10003, USA)

  • Chung-Yi Nien

    (New York University, 100 Washington Square East, New York, New York 10003, USA)

  • Hsiao-Yun Liu

    (New York University, 100 Washington Square East, New York, New York 10003, USA)

  • Mark M. Metzstein

    (Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA)

  • Nikolai Kirov

    (New York University, 100 Washington Square East, New York, New York 10003, USA)

  • Christine Rushlow

    (New York University, 100 Washington Square East, New York, New York 10003, USA)

Abstract

The zygotic genome takes charge The earliest events of embryogenesis are controlled by maternal gene products in the oocyte, however, at some point after fertilization the zygotic genome becomes activated. It is known that many of the early transcribed genes in Drosophila share a cis-regulatory heptamer motif. This paper reports that the zinc-finger protein, Zelda (Zld), binds specifically to these sites, and is capable of activating transcription in transient transfection assays. Mutant embryos lacking this protein are defective in the cellularization process, and fail to activate many genes essential for cellularization, sex determination, and dorsoventral patterning.

Suggested Citation

  • Hsiao-Lan Liang & Chung-Yi Nien & Hsiao-Yun Liu & Mark M. Metzstein & Nikolai Kirov & Christine Rushlow, 2008. "The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila," Nature, Nature, vol. 456(7220), pages 400-403, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7220:d:10.1038_nature07388
    DOI: 10.1038/nature07388
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    Cited by:

    1. Chun-Yi Cho & Patrick H. O’Farrell, 2023. "Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Dafne Ibarra-Morales & Michael Rauer & Piergiuseppe Quarato & Leily Rabbani & Fides Zenk & Mariana Schulte-Sasse & Francesco Cardamone & Alejandro Gomez-Auli & Germano Cecere & Nicola Iovino, 2021. "Histone variant H2A.Z regulates zygotic genome activation," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Elizabeth D. Larson & Hideyuki Komori & Tyler J. Gibson & Cyrina M. Ostgaard & Danielle C. Hamm & Jack M. Schnell & Cheng-Yu Lee & Melissa M. Harrison, 2021. "Cell-type-specific chromatin occupancy by the pioneer factor Zelda drives key developmental transitions in Drosophila," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

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