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Comparative genomics of the neglected human malaria parasite Plasmodium vivax

Author

Listed:
  • Jane M. Carlton

    (The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    New York University Langone Medical Center, 341 East 25th Street, New York, New York 10010, USA)

  • John H. Adams

    (College of Public Health, University of South Florida, 3720 Spectrum Boulevard, Suite 304, Tampa, Florida 33612, USA)

  • Joana C. Silva

    (Department of Microbiology and Immunology,
    Institute for Genome Sciences,)

  • Shelby L. Bidwell

    (The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA)

  • Hernan Lorenzi

    (The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA)

  • Elisabet Caler

    (The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA)

  • Jonathan Crabtree

    (The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Institute for Genome Sciences,)

  • Samuel V. Angiuoli

    (Institute for Genome Sciences,
    Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland 20742, USA)

  • Emilio F. Merino

    (New York University Langone Medical Center, 341 East 25th Street, New York, New York 10010, USA)

  • Paolo Amedeo

    (The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA)

  • Qin Cheng

    (Drug Resistance and Diagnostics, Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks, Enoggera, Queensland 4051, Australia)

  • Richard M. R. Coulson

    (Microarray Group, European Bioinfomatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK)

  • Brendan S. Crabb

    (The Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia)

  • Hernando A. del Portillo

    (Barcelona Centre for International Health Research, Hospital Clinic/IDIBAPS, Universitat de Barcelona Roselló 132, 4a planta, 08036 Barcelona, Spain
    Institució Catalana de Recerca i Estudis Avançats, Passeig Lluís Companys, 23 08010 Barcelona, Spain)

  • Kobby Essien

    (University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Tamara V. Feldblyum

    (Institute for Genome Sciences,)

  • Carmen Fernandez-Becerra

    (Barcelona Centre for International Health Research, Hospital Clinic/IDIBAPS, Universitat de Barcelona Roselló 132, 4a planta, 08036 Barcelona, Spain)

  • Paul R. Gilson

    (The Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia)

  • Amy H. Gueye

    (Hood College, Frederick, Maryland 21701, USA)

  • Xiang Guo

    (The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA)

  • Simon Kang’a

    (New York University Langone Medical Center, 341 East 25th Street, New York, New York 10010, USA)

  • Taco W. A. Kooij

    (Heidelberg University School of Medicine, Im Neuenheimer Feld 324, Heidelberg 69120, Germany)

  • Michael Korsinczky

    (Drug Resistance and Diagnostics, Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks, Enoggera, Queensland 4051, Australia
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia)

  • Esmeralda V.-S. Meyer

    (Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA)

  • Vish Nene

    (Department of Microbiology and Immunology,
    Institute for Genome Sciences,)

  • Ian Paulsen

    (The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Macquarie University, Sydney, New South Wales 2109, Australia)

  • Owen White

    (Institute for Genome Sciences,
    Department of Epidemiology and Preventive Medicine,)

  • Stuart A. Ralph

    (Bio21 Molecular Science and Biotechnology Institute, University of Melbourne)

  • Qinghu Ren

    (The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA)

  • Tobias J. Sargeant

    (The Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    University of Melbourne, Parkville, Victoria 3010, Australia)

  • Steven L. Salzberg

    (Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland 20742, USA)

  • Christian J. Stoeckert

    (University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • Steven A. Sullivan

    (New York University Langone Medical Center, 341 East 25th Street, New York, New York 10010, USA)

  • Marcio M. Yamamoto

    (Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Lineu Prestes 1374, São Paulo, São Paulo 05508-900, Brazil)

  • Stephen L. Hoffman

    (Sanaria Inc., 9800 Medical Center Drive, Rockville, Maryland 20850, USA)

  • Jennifer R. Wortman

    (Institute for Genome Sciences,
    University of Maryland School of Medicine, 20 Penn Street, Baltimore, Maryland 21201, USA)

  • Malcolm J. Gardner

    (The Institute for Genomic Research/J. Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Present address: Seattle Biomedical Research Center, 307 Westlake Avenue N., Suite 500, Seattle, Washington 98109-5219, USA.)

  • Mary R. Galinski

    (Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia)

  • John W. Barnwell

    (Malaria Branch, National Center for Zoonotic, Vector-borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA)

  • Claire M. Fraser-Liggett

    (Institute for Genome Sciences,
    University of Maryland School of Medicine, 20 Penn Street, Baltimore, Maryland 21201, USA)

Abstract

The human malaria parasite Plasmodium vivax is responsible for 25–40% of the ∼515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.

Suggested Citation

  • Jane M. Carlton & John H. Adams & Joana C. Silva & Shelby L. Bidwell & Hernan Lorenzi & Elisabet Caler & Jonathan Crabtree & Samuel V. Angiuoli & Emilio F. Merino & Paolo Amedeo & Qin Cheng & Richard , 2008. "Comparative genomics of the neglected human malaria parasite Plasmodium vivax," Nature, Nature, vol. 455(7214), pages 757-763, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7214:d:10.1038_nature07327
    DOI: 10.1038/nature07327
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    Cited by:

    1. Brittany Hazzard & Juliana M. Sá & Haikel N. Bogale & Tales V. Pascini & Angela C. Ellis & Shuchi Amin & Jennifer S. Armistead & John H. Adams & Thomas E. Wellems & David Serre, 2024. "Single-cell analyses of polyclonal Plasmodium vivax infections and their consequences on parasite transmission," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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