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The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

Author

Listed:
  • Min Sup Song

    (Cancer Genetics Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Leonardo Salmena

    (Cancer Genetics Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Arkaitz Carracedo

    (Cancer Genetics Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Ainara Egia

    (Cancer Genetics Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Francesco Lo-Coco

    (University of Tor Vergata)

  • Julie Teruya-Feldstein

    (Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, 1275 York Avenue, New York, New York 10021, USA)

  • Pier Paolo Pandolfi

    (Cancer Genetics Program, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

Abstract

PTEN ubiquitinylation in cancer The exclusion of the tumour suppressor PTEN from the cell nucleus has been linked with tumour progression; the mechanisms behind its aberrant localization are obscure, although ubiquitinylation of specific lysines in PTEN is known to regulate PTEN distribution between the cytoplasm and nucleus. Now Min Sup Song identify HAUSP, a deubiquitinating enzyme previously shown to act on the p53 tumour repressor, as the enzyme responsible for PTEN deubiquitination too. This activity is shown to regulate the cellular localization and function of PTEN. This role of HAUSP is antagonized by PML, another tumour suppressor. PML function is disrupted in promeyelocytic leukaemia, and drugs that are effective in treating this form of leukaemia are found to impinge on PTEN function, by affecting PML and HAUSP.

Suggested Citation

  • Min Sup Song & Leonardo Salmena & Arkaitz Carracedo & Ainara Egia & Francesco Lo-Coco & Julie Teruya-Feldstein & Pier Paolo Pandolfi, 2008. "The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network," Nature, Nature, vol. 455(7214), pages 813-817, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7214:d:10.1038_nature07290
    DOI: 10.1038/nature07290
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    Cited by:

    1. Mengjia Lin & Xiaoyun Zheng & Jianing Yan & Fei Huang & Yilin Chen & Ran Ding & Jinkai Wan & Lei Zhang & Chenliang Wang & Jinchang Pan & Xiaolei Cao & Kaiyi Fu & Yan Lou & Xin-Hua Feng & Junfang Ji & , 2024. "The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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