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Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

Author

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  • Katharina Brandl

    (Infectious Diseases Service, Immunology Program, Sloan-Kettering Institute
    Present addresses: Department of Genetics, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA (K.B.); Department of Infectious Diseases, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA (C.N.M.); Department of Medicine, University of California San Diego, La Jolla, California 92093, USA (B.S.).)

  • George Plitas

    (Hepatobiliary Service,)

  • Coralia N. Mihu

    (Infectious Diseases Service, Immunology Program, Sloan-Kettering Institute
    Present addresses: Department of Genetics, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA (K.B.); Department of Infectious Diseases, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA (C.N.M.); Department of Medicine, University of California San Diego, La Jolla, California 92093, USA (B.S.).)

  • Carles Ubeda

    (Infectious Diseases Service, Immunology Program, Sloan-Kettering Institute)

  • Ting Jia

    (Infectious Diseases Service, Immunology Program, Sloan-Kettering Institute)

  • Martin Fleisher

    (Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA)

  • Bernd Schnabl

    (Columbia University, New York, New York 10032, USA
    Present addresses: Department of Genetics, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA (K.B.); Department of Infectious Diseases, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA (C.N.M.); Department of Medicine, University of California San Diego, La Jolla, California 92093, USA (B.S.).)

  • Ronald P. DeMatteo

    (Hepatobiliary Service,)

  • Eric G. Pamer

    (Infectious Diseases Service, Immunology Program, Sloan-Kettering Institute
    Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA)

Abstract

Antibiotic-resistant bacteria: why are they so successful? Why antibiotic-resistant bacteria are so successful at causing infections in patients being treated with antibiotics is a something of a mystery. One previously unrecognized factor is reported in this issue: treatment with the broad-spectrum antibiotic vancomycin increases infection with resistant bacteria by compromising intestinal innate immunity. In mice receiving the antibiotic, intestinal expression of the antimicrobial protein, RegIIIγ was suppressed. RegIIIγ is notably effective against vancomycin-resistant Enterococcus (VRE), a common infection in hospitalized patients. Therapies that increase levels of this protein, such as orally administered lipopolysaccharide, may therefore be of use in patients receiving broad-spectrum antibiotics.

Suggested Citation

  • Katharina Brandl & George Plitas & Coralia N. Mihu & Carles Ubeda & Ting Jia & Martin Fleisher & Bernd Schnabl & Ronald P. DeMatteo & Eric G. Pamer, 2008. "Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits," Nature, Nature, vol. 455(7214), pages 804-807, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7214:d:10.1038_nature07250
    DOI: 10.1038/nature07250
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    Cited by:

    1. Sandrine Isaac & Alejandra Flor-Duro & Gloria Carruana & Leonor Puchades-Carrasco & Anna Quirant & Marina Lopez-Nogueroles & Antonio Pineda-Lucena & Marc Garcia-Garcera & Carles Ubeda, 2022. "Microbiome-mediated fructose depletion restricts murine gut colonization by vancomycin-resistant Enterococcus," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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