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ATP drives lamina propria TH17 cell differentiation

Author

Listed:
  • Koji Atarashi

    (Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Junichi Nishimura

    (Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan)

  • Tatsuichiro Shima

    (Yakult Central Institute for Microbiological Research, Yaho 1796, Kunitachi, Tokyo 186-8650, Japan)

  • Yoshinori Umesaki

    (Yakult Central Institute for Microbiological Research, Yaho 1796, Kunitachi, Tokyo 186-8650, Japan)

  • Masahiro Yamamoto

    (Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    WPI Immunology Frontier Research Center, Osaka University)

  • Masaharu Onoue

    (Yakult Central Institute for Microbiological Research, Yaho 1796, Kunitachi, Tokyo 186-8650, Japan)

  • Hideo Yagita

    (Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan)

  • Naoto Ishii

    (Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan)

  • Richard Evans

    (Henry Wellcome Building 2/59b, University of Leicester)

  • Kenya Honda

    (Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    WPI Immunology Frontier Research Center, Osaka University)

  • Kiyoshi Takeda

    (Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    WPI Immunology Frontier Research Center, Osaka University)

Abstract

Bacterial ATP helps TH17 cells The intestinal lamina propria, a layer of cells forming part of the mucous membrane, boasts a complicated mix of cell populations, including the selective presence of TH17 or T helper 17 cells, the subset of T helpers that produces interleukin 17. A study in mice now shows that commensal bacteria activate a unique subset of intestinal dendritic cells to induce interleukin-6 production and TGF-beta activation, thereby promoting the local differentiation of TH17 cells. It is the ATP that the bacteria produce that promotes this effect. This finding highlights the importance of commensal bacteria and ATP in immuno-logical diseases, and may help in determining the mechanisms by which aberrant TH17 cell responses result in immune disorders including inflammatory bowel diseases.

Suggested Citation

  • Koji Atarashi & Junichi Nishimura & Tatsuichiro Shima & Yoshinori Umesaki & Masahiro Yamamoto & Masaharu Onoue & Hideo Yagita & Naoto Ishii & Richard Evans & Kenya Honda & Kiyoshi Takeda, 2008. "ATP drives lamina propria TH17 cell differentiation," Nature, Nature, vol. 455(7214), pages 808-812, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7214:d:10.1038_nature07240
    DOI: 10.1038/nature07240
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    Cited by:

    1. Adélaïde Gélineau & Geneviève Marcelin & Melissa Ouhachi & Sébastien Dussaud & Lise Voland & Raoul Manuel & Ines Baba & Christine Rouault & Laurent Yvan-Charvet & Karine Clément & Roxane Tussiwand & T, 2024. "Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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