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Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells

Author

Listed:
  • Adélaïde Gélineau

    (Hôpital de la Pitié-Salpêtrière)

  • Geneviève Marcelin

    (NutriOmics)

  • Melissa Ouhachi

    (Hôpital de la Pitié-Salpêtrière)

  • Sébastien Dussaud

    (Hôpital de la Pitié-Salpêtrière)

  • Lise Voland

    (NutriOmics)

  • Raoul Manuel

    (Hôpital de la Pitié-Salpêtrière)

  • Ines Baba

    (Hôpital de la Pitié-Salpêtrière)

  • Christine Rouault

    (NutriOmics)

  • Laurent Yvan-Charvet

    (Fédération Hospitalo-Universitaire (FHU) Oncoage)

  • Karine Clément

    (NutriOmics
    Hôpital de la Pitié-Salpêtrière, service de Nutrition)

  • Roxane Tussiwand

    (National Institutes of Health)

  • Thierry Huby

    (Hôpital de la Pitié-Salpêtrière)

  • Emmanuel L. Gautier

    (Hôpital de la Pitié-Salpêtrière)

Abstract

Diet composition impacts metabolic health and is now recognized to shape the immune system, especially in the intestinal tract. Nutritional imbalance and increased caloric intake are induced by high-fat diet (HFD) in which lipids are enriched at the expense of dietary fibers. Such nutritional challenge alters glucose homeostasis as well as intestinal immunity. Here, we observed that short-term HFD induced dysbiosis, glucose intolerance and decreased intestinal RORγt+ CD4 T cells, including peripherally-induced Tregs and IL17-producing (Th17) T cells. However, supplementation of HFD-fed male mice with the fermentable dietary fiber fructooligosaccharides (FOS) was sufficient to maintain RORγt+ CD4 T cell subsets and microbial species known to induce them, alongside having a beneficial impact on glucose tolerance. FOS-mediated normalization of Th17 cells and amelioration of glucose handling required the cDC2 dendritic cell subset in HFD-fed animals, while IL-17 neutralization limited FOS impact on glucose tolerance. Overall, we uncover a pivotal role of cDC2 in the control of the immune and metabolic effects of FOS in the context of HFD feeding.

Suggested Citation

  • Adélaïde Gélineau & Geneviève Marcelin & Melissa Ouhachi & Sébastien Dussaud & Lise Voland & Raoul Manuel & Ines Baba & Christine Rouault & Laurent Yvan-Charvet & Karine Clément & Roxane Tussiwand & T, 2024. "Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49820-x
    DOI: 10.1038/s41467-024-49820-x
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    References listed on IDEAS

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    1. Blossom Akagbosu & Zakieh Tayyebi & Gayathri Shibu & Yoselin A. Paucar Iza & Deeksha Deep & Yollanda Franco Parisotto & Logan Fisher & H. Amalia Pasolli & Valentin Thevin & Rasa Elmentaite & Maximilia, 2022. "Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota," Nature, Nature, vol. 610(7933), pages 752-760, October.
    2. Koji Atarashi & Junichi Nishimura & Tatsuichiro Shima & Yoshinori Umesaki & Masahiro Yamamoto & Masaharu Onoue & Hideo Yagita & Naoto Ishii & Richard Evans & Kenya Honda & Kiyoshi Takeda, 2008. "ATP drives lamina propria TH17 cell differentiation," Nature, Nature, vol. 455(7214), pages 808-812, October.
    3. Mengze Lyu & Hiroaki Suzuki & Lan Kang & Fabrina Gaspal & Wenqing Zhou & Jeremy Goc & Lei Zhou & Jordan Zhou & Wen Zhang & Zeli Shen & James G. Fox & Robbyn E. Sockolow & Terri M. Laufer & Yong Fan & , 2022. "ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut," Nature, Nature, vol. 610(7933), pages 744-751, October.
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