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Modelling Myc inhibition as a cancer therapy

Author

Listed:
  • Laura Soucek

    (University of California, San Francisco, California 94143-0875, USA)

  • Jonathan Whitfield

    (University of California, San Francisco, California 94143-0875, USA)

  • Carla P. Martins

    (University of California, San Francisco, California 94143-0875, USA)

  • Andrew J. Finch

    (University of California, San Francisco, California 94143-0875, USA)

  • Daniel J. Murphy

    (University of California, San Francisco, California 94143-0875, USA)

  • Nicole M. Sodir

    (University of California, San Francisco, California 94143-0875, USA)

  • Anthony N. Karnezis

    (University of California, San Francisco, California 94143-0875, USA)

  • Lamorna Brown Swigart

    (University of California, San Francisco, California 94143-0875, USA)

  • Sergio Nasi

    (Istituto di Biologia e Patologia Molecolari, C.N.R., University La Sapienza)

  • Gerard I. Evan

    (University of California, San Francisco, California 94143-0875, USA)

Abstract

Myc back in the limelight The Myc gene encodes for a transcription factor that is central to gene regulation in normal cells. It is also an oncogene, overexpressed or amplified in many different types of tumour. Though this makes it a candidate target for antitumour drugs, its involvement in many normal cell functions, lack of evidence of therapeutic efficacy and the difficulty of targeting it mean that it is not top of many lists of potential targets. That could change. Using a mouse model of Ras-dependent lung cancer in which Myc function can in effect be turned on and off, Soucek et al. show that inhibition of endogenous Myc triggers tumour regression. Significantly, although systemic inhibition of Myc has effects in other tissues, these were readily reversible, suggesting that Myc might be a valid anticancer target.

Suggested Citation

  • Laura Soucek & Jonathan Whitfield & Carla P. Martins & Andrew J. Finch & Daniel J. Murphy & Nicole M. Sodir & Anthony N. Karnezis & Lamorna Brown Swigart & Sergio Nasi & Gerard I. Evan, 2008. "Modelling Myc inhibition as a cancer therapy," Nature, Nature, vol. 455(7213), pages 679-683, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7213:d:10.1038_nature07260
    DOI: 10.1038/nature07260
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    Citations

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    Cited by:

    1. Sukanya Panja & Mihai Ioan Truica & Christina Y. Yu & Vamshi Saggurthi & Michael W. Craige & Katie Whitehead & Mayra V. Tuiche & Aymen Al-Saadi & Riddhi Vyas & Shridar Ganesan & Suril Gohel & Frederic, 2024. "Mechanism-centric regulatory network identifies NME2 and MYC programs as markers of Enzalutamide resistance in CRPC," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    2. Laura Curti & Sara Rohban & Nicola Bianchi & Ottavio Croci & Adrian Andronache & Sara Barozzi & Michela Mattioli & Fernanda Ricci & Elena Pastori & Silvia Sberna & Simone Bellotti & Anna Accialini & R, 2024. "CDK12 controls transcription at damaged genes and prevents MYC-induced transcription-replication conflicts," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Nicole M. Sodir & Luca Pellegrinet & Roderik M. Kortlever & Tania Campos & Yong-Won Kwon & Shinseog Kim & Daniel Garcia & Alessandra Perfetto & Panayiotis Anastasiou & Lamorna Brown Swigart & Mark J. , 2022. "Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Yuri Frosi & Yen-Chu Lin & Jiang Shimin & Siti Radhiah Ramlan & Kelly Hew & Alf Henrik Engman & Anil Pillai & Kit Yeung & Yue Xiang Cheng & Tobias Cornvik & Par Nordlund & Megan Goh & Dilraj Lama & Za, 2022. "Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    5. William Senapedis & Kayleigh M. Gallagher & Elmer Figueroa & Jeremiah D. Farelli & Robert Lyng & J. Graeme Hodgson & Charles W. O’Donnell & Joseph V. Newman & Madison Pacaro & Stephen K. Siecinski & J, 2024. "Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Dilraj Lama & Thibault Vosselman & Cagla Sahin & Judit Liaño-Pons & Carmine P. Cerrato & Lennart Nilsson & Kaare Teilum & David P. Lane & Michael Landreh & Marie Arsenian Henriksson, 2024. "A druggable conformational switch in the c-MYC transactivation domain," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    7. Anja Deutzmann & Delaney K. Sullivan & Renumathy Dhanasekaran & Wei Li & Xinyu Chen & Ling Tong & Wadie D. Mahauad-Fernandez & John Bell & Adriane Mosley & Angela N. Koehler & Yulin Li & Dean W. Felsh, 2024. "Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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