IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v455y2008i7213d10.1038_nature07260.html
   My bibliography  Save this article

Modelling Myc inhibition as a cancer therapy

Author

Listed:
  • Laura Soucek

    (University of California, San Francisco, California 94143-0875, USA)

  • Jonathan Whitfield

    (University of California, San Francisco, California 94143-0875, USA)

  • Carla P. Martins

    (University of California, San Francisco, California 94143-0875, USA)

  • Andrew J. Finch

    (University of California, San Francisco, California 94143-0875, USA)

  • Daniel J. Murphy

    (University of California, San Francisco, California 94143-0875, USA)

  • Nicole M. Sodir

    (University of California, San Francisco, California 94143-0875, USA)

  • Anthony N. Karnezis

    (University of California, San Francisco, California 94143-0875, USA)

  • Lamorna Brown Swigart

    (University of California, San Francisco, California 94143-0875, USA)

  • Sergio Nasi

    (Istituto di Biologia e Patologia Molecolari, C.N.R., University La Sapienza)

  • Gerard I. Evan

    (University of California, San Francisco, California 94143-0875, USA)

Abstract

Myc back in the limelight The Myc gene encodes for a transcription factor that is central to gene regulation in normal cells. It is also an oncogene, overexpressed or amplified in many different types of tumour. Though this makes it a candidate target for antitumour drugs, its involvement in many normal cell functions, lack of evidence of therapeutic efficacy and the difficulty of targeting it mean that it is not top of many lists of potential targets. That could change. Using a mouse model of Ras-dependent lung cancer in which Myc function can in effect be turned on and off, Soucek et al. show that inhibition of endogenous Myc triggers tumour regression. Significantly, although systemic inhibition of Myc has effects in other tissues, these were readily reversible, suggesting that Myc might be a valid anticancer target.

Suggested Citation

  • Laura Soucek & Jonathan Whitfield & Carla P. Martins & Andrew J. Finch & Daniel J. Murphy & Nicole M. Sodir & Anthony N. Karnezis & Lamorna Brown Swigart & Sergio Nasi & Gerard I. Evan, 2008. "Modelling Myc inhibition as a cancer therapy," Nature, Nature, vol. 455(7213), pages 679-683, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7213:d:10.1038_nature07260
    DOI: 10.1038/nature07260
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07260
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07260?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sukanya Panja & Mihai Ioan Truica & Christina Y. Yu & Vamshi Saggurthi & Michael W. Craige & Katie Whitehead & Mayra V. Tuiche & Aymen Al-Saadi & Riddhi Vyas & Shridar Ganesan & Suril Gohel & Frederic, 2024. "Mechanism-centric regulatory network identifies NME2 and MYC programs as markers of Enzalutamide resistance in CRPC," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    2. Nicole M. Sodir & Luca Pellegrinet & Roderik M. Kortlever & Tania Campos & Yong-Won Kwon & Shinseog Kim & Daniel Garcia & Alessandra Perfetto & Panayiotis Anastasiou & Lamorna Brown Swigart & Mark J. , 2022. "Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Yuri Frosi & Yen-Chu Lin & Jiang Shimin & Siti Radhiah Ramlan & Kelly Hew & Alf Henrik Engman & Anil Pillai & Kit Yeung & Yue Xiang Cheng & Tobias Cornvik & Par Nordlund & Megan Goh & Dilraj Lama & Za, 2022. "Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    4. Dilraj Lama & Thibault Vosselman & Cagla Sahin & Judit Liaño-Pons & Carmine P. Cerrato & Lennart Nilsson & Kaare Teilum & David P. Lane & Michael Landreh & Marie Arsenian Henriksson, 2024. "A druggable conformational switch in the c-MYC transactivation domain," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Anja Deutzmann & Delaney K. Sullivan & Renumathy Dhanasekaran & Wei Li & Xinyu Chen & Ling Tong & Wadie D. Mahauad-Fernandez & John Bell & Adriane Mosley & Angela N. Koehler & Yulin Li & Dean W. Felsh, 2024. "Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:455:y:2008:i:7213:d:10.1038_nature07260. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.