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Type IV collagens regulate BMP signalling in Drosophila

Author

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  • Xiaomeng Wang

    (Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK)

  • Robin E. Harris

    (Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK)

  • Laura J. Bayston

    (Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK)

  • Hilary L. Ashe

    (Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK)

Abstract

Dorsal–ventral patterning in vertebrate and invertebrate embryos is mediated by a conserved system of secreted proteins that establishes a bone morphogenetic protein (BMP) gradient. Although the Drosophila embryonic Decapentaplegic (Dpp) gradient has served as a model to understand how morphogen gradients are established, no role for the extracellular matrix has been previously described. Here we show that type IV collagen extracellular matrix proteins bind Dpp and regulate its signalling in both the Drosophila embryo and ovary. We provide evidence that the interaction between Dpp and type IV collagen augments Dpp signalling in the embryo by promoting gradient formation, yet it restricts the signalling range in the ovary through sequestration of the Dpp ligand. Together, these results identify a critical function of type IV collagens in modulating Dpp in the extracellular space during Drosophila development. On the basis of our findings that human type IV collagen binds BMP4, we predict that this role of type IV collagens will be conserved.

Suggested Citation

  • Xiaomeng Wang & Robin E. Harris & Laura J. Bayston & Hilary L. Ashe, 2008. "Type IV collagens regulate BMP signalling in Drosophila," Nature, Nature, vol. 455(7209), pages 72-77, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7209:d:10.1038_nature07214
    DOI: 10.1038/nature07214
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    Cited by:

    1. Joel T. Rämö & Tuomo Kiiskinen & Richard Seist & Kristi Krebs & Masahiro Kanai & Juha Karjalainen & Mitja Kurki & Eija Hämäläinen & Paavo Häppölä & Aki S. Havulinna & Heidi Hautakangas & Reedik Mägi &, 2023. "Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Sharif M. Ridwan & Autumn Twillie & Samaneh Poursaeid & Emma Kristine Beard & Muhammed Burak Bener & Matthew Antel & Ann E. Cowan & Shinya Matsuda & Mayu Inaba, 2024. "Diffusible fraction of niche BMP ligand safeguards stem-cell differentiation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Timo Kuhn & Amit N. Landge & David Mörsdorf & Jonas Coßmann & Johanna Gerstenecker & Daniel Čapek & Patrick Müller & J. Christof M. Gebhardt, 2022. "Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Michael Pargett & Ann E Rundell & Gregery T Buzzard & David M Umulis, 2014. "Model-Based Analysis for Qualitative Data: An Application in Drosophila Germline Stem Cell Regulation," PLOS Computational Biology, Public Library of Science, vol. 10(3), pages 1-18, March.

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