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Puzzles, promises and a cure for ageing

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  • Jan Vijg

    (Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
    Present address: Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.)

  • Judith Campisi

    (Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
    Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 84–171, Berkeley, California 94720, USA)

Abstract

The human lifespan: how far can you go? Research on lab organisms such as yeast, worms and mice has encouraged the notion that lifespan is plastic, something to be manipulated genetically, with drugs or by nutritional fine-tuning. The big question is how — or whether — this work translates to the human condition. In a review, Jan Vijg and Judith Campisi discuss current knowledge about factors that limit human lifespan. They conclude that it is too early to say whether it is feasible to postpone human ageing and natural death for many decades. And they outline questions that future research needs to answer if we are to develop integrated strategies capable of increasing human health and lifespan.

Suggested Citation

  • Jan Vijg & Judith Campisi, 2008. "Puzzles, promises and a cure for ageing," Nature, Nature, vol. 454(7208), pages 1065-1071, August.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7208:d:10.1038_nature07216
    DOI: 10.1038/nature07216
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    Cited by:

    1. Matías Quer, 2020. "Fear of Death as the Foundation of Modern Political Philosophy and Its Overcoming by Transhumanism," Postmodern Openings, Editura Lumen, Department of Economics, vol. 11(4), pages 323-333, December.
    2. Joseph T Glessner & Albert Vernon Smith & Saarene Panossian & Cecilia E Kim & Nagahide Takahashi & Kelly A Thomas & Fengxiang Wang & Kallyn Seidler & Tamara B Harris & Lenore J Launer & Brendan Keatin, 2013. "Copy Number Variations in Alternative Splicing Gene Networks Impact Lifespan," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-11, January.
    3. Arthur Fischbach & Angela Johns & Kara L. Schneider & Xinxin Hao & Peter Tessarz & Thomas Nyström, 2023. "Artificial Hsp104-mediated systems for re-localizing protein aggregates," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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