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Acetylcholine contributes through muscarinic receptors to attentional modulation in V1

Author

Listed:
  • J. L. Herrero

    (Institute of Neuroscience, Newcastle University)

  • M. J. Roberts

    (Institute of Neuroscience, Newcastle University
    Present addresses: F. C. Donders Centre for Cognitive Neuroimaging, PO Box 9101, 6500 HB Nijmegen, The Netherlands (M.J.R.); Department of Psychology, School of Business, Law & Psychology, University of Sunderland, Sunderland SR6 0DD, UK (L.S.D.).)

  • L. S. Delicato

    (Institute of Neuroscience, Newcastle University
    Present addresses: F. C. Donders Centre for Cognitive Neuroimaging, PO Box 9101, 6500 HB Nijmegen, The Netherlands (M.J.R.); Department of Psychology, School of Business, Law & Psychology, University of Sunderland, Sunderland SR6 0DD, UK (L.S.D.).)

  • M. A. Gieselmann

    (Institute of Neuroscience, Newcastle University)

  • P. Dayan

    (Gatsby Computational Neuroscience Unit, University College London, 17 Queens Square, London WCIN 3AR, UK)

  • A. Thiele

    (Institute of Neuroscience, Newcastle University)

Abstract

Attention seeking: a role for acetylcholine If you find yourself needing to reread this paragraph, perhaps it's not that well written. Or it may be that you are low on acetylcholine. Cortical sensory processing is critically modulated by selective attention, but how this modulation is mediated is a long-standing unresolved issue. In tests in macaque monkeys trained to detect a flashing object but to ignore another one flashing nearby, the application of the neurotransmitter acetylcholine into the visual cortex enhanced the monkeys' performance. Applications of muscarinic — but not nicotinic — antagonists had the opposite effect. This suggests that this experiment may have pinpointed a brain mechanism that allows us to block out other stimuli while trying to concentrate on a particular thing.

Suggested Citation

  • J. L. Herrero & M. J. Roberts & L. S. Delicato & M. A. Gieselmann & P. Dayan & A. Thiele, 2008. "Acetylcholine contributes through muscarinic receptors to attentional modulation in V1," Nature, Nature, vol. 454(7208), pages 1110-1114, August.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7208:d:10.1038_nature07141
    DOI: 10.1038/nature07141
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    Cited by:

    1. Noel Federman & Sebastián A. Romano & Macarena Amigo-Duran & Lucca Salomon & Antonia Marin-Burgin, 2024. "Acquisition of non-olfactory encoding improves odour discrimination in olfactory cortex," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Anthony Renard & Evan R. Harrell & Brice Bathellier, 2022. "Olfactory modulation of barrel cortex activity during active whisking and passive whisker stimulation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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