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Mouse development with a single E2F activator

Author

Listed:
  • Shih-Yin Tsai

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine)

  • Rene Opavsky

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine)

  • Nidhi Sharma

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine)

  • Lizhao Wu

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine
    Present address: Department of Cell Biology and Molecular Medicine and University Hospital Cancer Center, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103, USA.)

  • Shan Naidu

    (Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine
    College of Veterinary Medicine, and)

  • Eric Nolan

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine)

  • Enrique Feria-Arias

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine)

  • Cynthia Timmers

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine)

  • Jana Opavska

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine)

  • Alain de Bruin

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine)

  • Jean-Leon Chong

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine)

  • Prashant Trikha

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine)

  • Soledad A. Fernandez

    (Center for Biostatistics, The Ohio State University, Columbus, Ohio 43210, USA)

  • Paul Stromberg

    (College of Veterinary Medicine, and)

  • Thomas J. Rosol

    (College of Veterinary Medicine, and)

  • Gustavo Leone

    (College of Biological Sciences
    Human Cancer Genetics Program, Comprehensive Cancer Center,
    College of Medicine)

Abstract

E2F proteins: reasons for diversity The E2F family is a family of proteins, some of which act as transcription activators and others as repressors. Here Shih-Yin Tsai et al. tested why there is such genetic complexity by inactivating the entire subset of activators singly or in combination in mice. They show that E2f3a is sufficient to support mouse embryonic and postnatal development. However, expression of E2f3b or E2f1 from the E2f3a locus suppressed all the postnatal phenotypes associated with the inactivation of E2f3a. They conclude there is functional redundancy among activators and that the requirement for E2f3a during postnatal development is dictated by its regulatory sequences, not by its protein function. These findings provide a molecular basis for the observed specificity among E2F activators during development.

Suggested Citation

  • Shih-Yin Tsai & Rene Opavsky & Nidhi Sharma & Lizhao Wu & Shan Naidu & Eric Nolan & Enrique Feria-Arias & Cynthia Timmers & Jana Opavska & Alain de Bruin & Jean-Leon Chong & Prashant Trikha & Soledad , 2008. "Mouse development with a single E2F activator," Nature, Nature, vol. 454(7208), pages 1137-1141, August.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7208:d:10.1038_nature07066
    DOI: 10.1038/nature07066
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    Cited by:

    1. Andrea Riba & Attila Oravecz & Matej Durik & Sara Jiménez & Violaine Alunni & Marie Cerciat & Matthieu Jung & Céline Keime & William M. Keyes & Nacho Molina, 2022. "Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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