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Drosophila RNAi screen identifies host genes important for influenza virus replication

Author

Listed:
  • Linhui Hao

    (Institute for Molecular Virology,
    Howard Hughes Medical Institute,)

  • Akira Sakurai

    (and
    Present address: First Department of Forensic Science, National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa 277-0882, Japan.)

  • Tokiko Watanabe

    (and)

  • Ericka Sorensen

    (Institute for Molecular Virology,)

  • Chairul A. Nidom

    (Faculty of Veterinary Medicine, and,
    Collaborating Research Center-Emerging & Reemerging Infectious Diseases, Tropical Disease Centre, Airlangga University, Surabaya 60115, Indonesia)

  • Michael A. Newton

    (University of Wisconsin-Madison, Madison, Wisconsin 53706, USA)

  • Paul Ahlquist

    (Institute for Molecular Virology,
    Howard Hughes Medical Institute,)

  • Yoshihiro Kawaoka

    (and
    and
    International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
    Graduate School of Medicine, Kobe University)

Abstract

Flu in a fruit fly: the search for new antivirals Although several alternative antivirals are available for the treatment of influenza virus infection, the risk that viruses resistant to these drugs will emerge means it is important to continue the search for new antiviral targets. Hao et al. have recruited a new ally to this cause: by modifying influenza virus so that it can infect the cells of the fruit fly Drosophila, they have been able to use a powerful genome-wide RNA interference (RNAi) screen to identify scores of host genes that the pathogen requires for successful infection. Several host proteins were found that have key functions in the replication of H5N1 and H1N1 influenza A viruses — but not other viruses — in human cells. The same strategy should be applicable to other viruses, as long as at least part of their replication cycle can be supported in Drosophila cells.

Suggested Citation

  • Linhui Hao & Akira Sakurai & Tokiko Watanabe & Ericka Sorensen & Chairul A. Nidom & Michael A. Newton & Paul Ahlquist & Yoshihiro Kawaoka, 2008. "Drosophila RNAi screen identifies host genes important for influenza virus replication," Nature, Nature, vol. 454(7206), pages 890-893, August.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7206:d:10.1038_nature07151
    DOI: 10.1038/nature07151
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    Cited by:

    1. Deborah Chasman & Brandi Gancarz & Linhui Hao & Michael Ferris & Paul Ahlquist & Mark Craven, 2014. "Inferring Host Gene Subnetworks Involved in Viral Replication," PLOS Computational Biology, Public Library of Science, vol. 10(5), pages 1-22, May.

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