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Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

Author

Listed:
  • Shidong Jia

    (Department of Cancer Biology and,
    Department of Pathology and,)

  • Zhenning Liu

    (Department of Cancer Biology and,
    Department of Pathology and,)

  • Sen Zhang

    (Department of Cancer Biology and,
    Department of Pathology and,)

  • Pixu Liu

    (Department of Cancer Biology and,
    Department of Pathology and,)

  • Lei Zhang

    (Department of Cancer Biology and,
    Department of Pathology and,)

  • Sang Hyun Lee

    (Department of Cancer Biology and,
    Department of Pathology and,)

  • Jing Zhang

    (Department of Cancer Biology and,
    Department of Pathology and,)

  • Sabina Signoretti

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Department of Pathology and,)

  • Massimo Loda

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Department of Pathology and,)

  • Thomas M. Roberts

    (Department of Cancer Biology and,
    Department of Pathology and,)

  • Jean J. Zhao

    (Department of Cancer Biology and,
    Department of Pathology and,
    Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Insulin-induced changes in tumours The two most widely expressed isoforms of class 1 PI3 kinases are p110alpha and p110beta. Previously, the p110-alpha isoform has been implicated in growth factor and insulin signalling, as well as in tumorigenesis. Now the analysis of mutant mice reveals a major role for p110-beta in the regulation of insulin-dependent metabolic changes and in tumour formation. Interestingly, some of the effects are mediated by a kinase-independent function of p110-beta.

Suggested Citation

  • Shidong Jia & Zhenning Liu & Sen Zhang & Pixu Liu & Lei Zhang & Sang Hyun Lee & Jing Zhang & Sabina Signoretti & Massimo Loda & Thomas M. Roberts & Jean J. Zhao, 2008. "Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis," Nature, Nature, vol. 454(7205), pages 776-779, August.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7205:d:10.1038_nature07091
    DOI: 10.1038/nature07091
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    Cited by:

    1. Sarah E. Conduit & Wayne Pearce & Amandeep Bhamra & Benoit Bilanges & Laura Bozal-Basterra & Lazaros C. Foukas & Mathias Cobbaut & Sandra D. Castillo & Mohammad Amin Danesh & Mahreen Adil & Arkaitz Ca, 2024. "A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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