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Essential role for Nix in autophagic maturation of erythroid cells

Author

Listed:
  • Hector Sandoval

    (Departments of Immunology,)

  • Perumal Thiagarajan

    (Pathology and,)

  • Swapan K. Dasgupta

    (Pathology and,)

  • Armin Schumacher

    (Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA)

  • Josef T. Prchal

    (University of Utah School of Medicine, Salt Lake City, Utah 84132, USA)

  • Min Chen

    (Departments of Immunology,)

  • Jin Wang

    (Departments of Immunology,)

Abstract

Erythroid cell maturation: Then need for Nix Erythroid cells undergo enucleation and the removal of organelles during terminal differentiation. This paper shows that a member of the Bcl-2 family, Nix/Bnip3L, helps eliminate organelles by by autophagy (or 'eating') of the mitochondria. Nix−/− mice developed anaemia with reduced mature erythrocytes and compensatory expansion of erythroid precursors. Erythrocytes in the peripheral blood of Nix−/− mice exhibited mitochondrial retention and reduced lifespan in vivo. This work may shed light on the mechanisms for various anaemic conditions associated with defective autophagy. It may also help to understand the molecular regulation of autophagy under normal and disease settings in other cell types.

Suggested Citation

  • Hector Sandoval & Perumal Thiagarajan & Swapan K. Dasgupta & Armin Schumacher & Josef T. Prchal & Min Chen & Jin Wang, 2008. "Essential role for Nix in autophagic maturation of erythroid cells," Nature, Nature, vol. 454(7201), pages 232-235, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7201:d:10.1038_nature07006
    DOI: 10.1038/nature07006
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    Cited by:

    1. Cheng-Wei Chang & Wei-Chung Cheng & Chaang-Ray Chen & Wun-Yi Shu & Min-Lung Tsai & Ching-Lung Huang & Ian C Hsu, 2011. "Identification of Human Housekeeping Genes and Tissue-Selective Genes by Microarray Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-10, July.
    2. Kao Li-Pin, 2017. "Autophagy and Mitophagy," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 7(1), pages 1-2, August.

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