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Autophagy and Mitophagy

Author

Listed:
  • Kao Li-Pin

    (Department of Medicine, Mayo Clinic, Scottsdale, USA
    Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Australia)

Abstract

Mitochondria are cellular organelles that are critical for energy production. They also serve as signalling hubs, integrating a variety of inputs related to metabolic demand, redox control, and apoptosis. The mass and quality of mitochondria within a cell are determined by a balance between mitochondrial biogenesis and mitochondrial turnover. It is important to understand how autophagy and mitophagy can specific play a role in the cell therapy field. A more thorough understanding of the molecular mechanisms controlling mitophagy in a homeostasis may eventually allow for manipulation of this process, a technology that could improve the mitochondrial quality in cell therapy and thus facilitate the therapeutic application of these cells in regenerative medicine.

Suggested Citation

  • Kao Li-Pin, 2017. "Autophagy and Mitophagy," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 7(1), pages 1-2, August.
    • Handle: RePEc:adp:jctbeb:v:7:y:2017:i:1:p:1-2
    DOI: 10.19080/CTBEB.2017.07.555701
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    References listed on IDEAS

    as
    1. Hector Sandoval & Perumal Thiagarajan & Swapan K. Dasgupta & Armin Schumacher & Josef T. Prchal & Min Chen & Jin Wang, 2008. "Essential role for Nix in autophagic maturation of erythroid cells," Nature, Nature, vol. 454(7201), pages 232-235, July.
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