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Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

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  • Ferdia A. Gallagher

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
    University of Cambridge, Level 5, Box 219, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK)

  • Mikko I. Kettunen

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK)

  • Sam E. Day

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
    Present address: Laboratory of Functional and Molecular Imaging, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1065, USA.)

  • De-En Hu

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK)

  • Jan Henrik Ardenkjær-Larsen

    (GE Healthcare, The Grove Centre GC/18, White Lion Road, Amersham HP7 9LL, UK)

  • René in ‘t Zandt

    (Imagnia AB, Box 8225, SE-200 41 Malmö, Sweden)

  • Pernille R. Jensen

    (Imagnia AB, Box 8225, SE-200 41 Malmö, Sweden)

  • Magnus Karlsson

    (Imagnia AB, Box 8225, SE-200 41 Malmö, Sweden)

  • Klaes Golman

    (Imagnia AB, Box 8225, SE-200 41 Malmö, Sweden)

  • Mathilde H. Lerche

    (Imagnia AB, Box 8225, SE-200 41 Malmö, Sweden)

  • Kevin M. Brindle

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK)

Abstract

Translational research: MRI litmus test for tumours A low tissue pH is often associated with disease — for example cancer, ischaemia and inflammation — so a technique that could image tissue pH would have considerable potential for disease diagnosis and for monitoring response to treatment. A new, non-invasive method of pH imaging has now been devised, and demonstrated by monitoring the extracellular pH in living mice. It combines magnetic resonance imaging (MRI) and the intravenous injection of carbon-13-labelled bicarbonate — made extremely sensitive to detection by the use of dynamic nuclear polarization. Bicarbonate is a natural buffer in mammalian tissues, resisting pH change via interconversion with carbon dioxide in the reaction catalysed by carbonic anhydrase. The ratio of labelled bicarbonate to carbon dioxide can be used to calculate pH from the Henderson-Hasselbalch equation.

Suggested Citation

  • Ferdia A. Gallagher & Mikko I. Kettunen & Sam E. Day & De-En Hu & Jan Henrik Ardenkjær-Larsen & René in ‘t Zandt & Pernille R. Jensen & Magnus Karlsson & Klaes Golman & Mathilde H. Lerche & Kevin M. B, 2008. "Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate," Nature, Nature, vol. 453(7197), pages 940-943, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7197:d:10.1038_nature07017
    DOI: 10.1038/nature07017
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    Cited by:

    1. Martin Grashei & Pascal Wodtke & Jason G. Skinner & Sandra Sühnel & Nadine Setzer & Thomas Metzler & Sebastian Gulde & Mihyun Park & Daniela Witt & Hermine Mohr & Christian Hundshammer & Nicole Stritt, 2023. "Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Clément Adam & Léa Paolini & Naïg Gueguen & Guillaume Mabilleau & Laurence Preisser & Simon Blanchard & Pascale Pignon & Florence Manero & Morgane Mao & Alain Morel & Pascal Reynier & Céline Beauvilla, 2021. "Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunction by metabolic reprograming," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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