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Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD

Author

Listed:
  • Martin Grashei

    (Technical University of Munich)

  • Pascal Wodtke

    (Technical University of Munich)

  • Jason G. Skinner

    (Technical University of Munich)

  • Sandra Sühnel

    (Technical University of Munich)

  • Nadine Setzer

    (Technical University of Munich)

  • Thomas Metzler

    (Technical University of Munich)

  • Sebastian Gulde

    (Helmholtz Zentrum München)

  • Mihyun Park

    (Technical University of Munich)

  • Daniela Witt

    (Technical University of Munich)

  • Hermine Mohr

    (Helmholtz Zentrum München)

  • Christian Hundshammer

    (Technical University of Munich)

  • Nicole Strittmatter

    (Technical University of Munich)

  • Natalia S. Pellegata

    (Helmholtz Zentrum München
    University of Pavia)

  • Katja Steiger

    (Technical University of Munich)

  • Franz Schilling

    (Technical University of Munich
    Technical University of Munich
    Partner Site Munich and German Cancer Research Center (DKFZ))

Abstract

pH alterations are a hallmark of many pathologies including cancer and kidney disease. Here, we introduce [1,5-13C2]Z-OMPD as a hyperpolarized extracellular pH and perfusion sensor for MRI which allows to generate a multiparametric fingerprint of renal disease status and to detect local tumor acidification. Exceptional long T1 of two minutes at 1 T, high pH sensitivity of up to 1.9 ppm per pH unit and suitability of using the C1-label as internal frequency reference enables pH imaging in vivo of three pH compartments in healthy rat kidneys. Spectrally selective targeting of both 13C-resonances enables simultaneous imaging of perfusion and filtration in 3D and pH in 2D within one minute to quantify renal blood flow, glomerular filtration rates and renal pH in healthy and hydronephrotic kidneys with superior sensitivity compared to clinical routine methods. Imaging multiple biomarkers within a single session renders [1,5-13C2]Z-OMPD a promising new hyperpolarized agent for oncology and nephrology.

Suggested Citation

  • Martin Grashei & Pascal Wodtke & Jason G. Skinner & Sandra Sühnel & Nadine Setzer & Thomas Metzler & Sebastian Gulde & Mihyun Park & Daniela Witt & Hermine Mohr & Christian Hundshammer & Nicole Stritt, 2023. "Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40747-3
    DOI: 10.1038/s41467-023-40747-3
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    References listed on IDEAS

    as
    1. Ferdia A. Gallagher & Mikko I. Kettunen & Sam E. Day & De-En Hu & Jan Henrik Ardenkjær-Larsen & René in ‘t Zandt & Pernille R. Jensen & Magnus Karlsson & Klaes Golman & Mathilde H. Lerche & Kevin M. B, 2008. "Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate," Nature, Nature, vol. 453(7197), pages 940-943, June.
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