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Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

Author

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  • Lars Guelen

    (Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Ludo Pagie

    (Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Emilie Brasset

    (Department of Cell Biology and Genetics and,)

  • Wouter Meuleman

    (Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Mekelweg 4, 2628 CD Delft, The Netherlands)

  • Marius B. Faza

    (Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Wendy Talhout

    (Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Bert H. Eussen

    (Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands)

  • Annelies de Klein

    (Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands)

  • Lodewyk Wessels

    (Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Mekelweg 4, 2628 CD Delft, The Netherlands)

  • Wouter de Laat

    (Department of Cell Biology and Genetics and,)

  • Bas van Steensel

    (Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

Abstract

Chromosomal organization: Nuclear lamina interactions The architecture of human chromosomes within the nucleus is still a mystery. The nuclear lamina is thought to anchor specific DNA elements to help organize the genome within the nucleus. Van Steensel and colleagues report a high-resolution map of the sites of the human genome that contact the nuclear lamina. The map shows that interactions with the lamina occur via large yet sharply demarcated genomic domains. This domain structure is linked to the epigenetic and transcriptional profile of the genome. Many domain borders are marked by specific sequence elements, indicating that the higher-order folding of chromosomes is in part encoded in the genome itself.

Suggested Citation

  • Lars Guelen & Ludo Pagie & Emilie Brasset & Wouter Meuleman & Marius B. Faza & Wendy Talhout & Bert H. Eussen & Annelies de Klein & Lodewyk Wessels & Wouter de Laat & Bas van Steensel, 2008. "Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions," Nature, Nature, vol. 453(7197), pages 948-951, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7197:d:10.1038_nature06947
    DOI: 10.1038/nature06947
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    Cited by:

    1. David E. Torres & H. Martin Kramer & Vittorio Tracanna & Gabriel L. Fiorin & David E. Cook & Michael F. Seidl & Bart P. H. J. Thomma, 2024. "Implications of the three-dimensional chromatin organization for genome evolution in a fungal plant pathogen," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Robert Schöpflin & Uirá Souto Melo & Hossein Moeinzadeh & David Heller & Verena Laupert & Jakob Hertzberg & Manuel Holtgrewe & Nico Alavi & Marius-Konstantin Klever & Julius Jungnitsch & Emel Comak & , 2022. "Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline rearranged genomes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Allison P. Siegenfeld & Shelby A. Roseman & Heejin Roh & Nicholas Z. Lue & Corin C. Wagen & Eric Zhou & Sarah E. Johnstone & Martin J. Aryee & Brian B. Liau, 2022. "Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Meng Zhang & Mary Elisabeth Ehmann & Srija Matukumalli & Aashutosh Girish Boob & David M. Gilbert & Huimin Zhao, 2023. "SHIELD: a platform for high-throughput screening of barrier-type DNA elements in human cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Cristiana Bersaglieri & Jelena Kresoja-Rakic & Shivani Gupta & Dominik Bär & Rostyslav Kuzyakiv & Martina Panatta & Raffaella Santoro, 2022. "Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    6. Miguel M. Álvarez & Josep Biayna & Fran Supek, 2022. "TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    7. Kaela M. Varberg & Esteban M. Dominguez & Boryana Koseva & Joseph M. Varberg & Ross P. McNally & Ayelen Moreno-Irusta & Emily R. Wesley & Khursheed Iqbal & Warren A. Cheung & Carl Schwendinger-Schreck, 2023. "Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    8. Carlos Díaz-Castillo, 2013. "Females and Males Contribute in Opposite Ways to the Evolution of Gene Order in Drosophila," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.
    9. Yi Li & James Lee & Lu Bai, 2024. "DNA methylation-based high-resolution mapping of long-distance chromosomal interactions in nucleosome-depleted regions," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    10. Timothy A. Daugird & Yu Shi & Katie L. Holland & Hosein Rostamian & Zhe Liu & Luke D. Lavis & Joseph Rodriguez & Brian D. Strahl & Wesley R. Legant, 2024. "Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    11. Judith H. I. Haarhuis & Robin H. Weide & Vincent A. Blomen & Koen D. Flach & Hans Teunissen & Laureen Willems & Thijn R. Brummelkamp & Benjamin D. Rowland & Elzo Wit, 2022. "A Mediator-cohesin axis controls heterochromatin domain formation," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    12. Frederic Li Mow Chee & Bruno Beernaert & Billie G. C. Griffith & Alexander E. P. Loftus & Yatendra Kumar & Jimi C. Wills & Martin Lee & Jessica Valli & Ann P. Wheeler & J. Douglas Armstrong & Maddy Pa, 2023. "Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    13. Peter Henneman & Arjan Bouman & Adri Mul & Lia Knegt & Anne-Marie van der Kevie-Kersemaekers & Nitash Zwaveling-Soonawala & Hanne E J Meijers-Heijboer & A S Paul van Trotsenburg & Marcel M Mannens, 2018. "Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonates," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-19, March.

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