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Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

Author

Listed:
  • Oliver H. Tam

    (Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Alexei A. Aravin

    (Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Paula Stein

    (University of Pennsylvania, 433 South University Avenue, 205 Lynch Laboratories, Philadelphia, Pennsylvania 19104-6018, USA)

  • Angelique Girard

    (Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Elizabeth P. Murchison

    (Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Sihem Cheloufi

    (Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Emily Hodges

    (Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Martin Anger

    (University of Pennsylvania, 433 South University Avenue, 205 Lynch Laboratories, Philadelphia, Pennsylvania 19104-6018, USA
    Present address: University of Oxford, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK.)

  • Ravi Sachidanandam

    (Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Richard M. Schultz

    (University of Pennsylvania, 433 South University Avenue, 205 Lynch Laboratories, Philadelphia, Pennsylvania 19104-6018, USA)

  • Gregory J. Hannon

    (Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

Abstract

Pseudogenes: Not without influence Over evolutionary time, many genes undergo duplication and one copy accumulates mutations that render it non-functional. These 'pseudogenes' are generally thought to be rather uninteresting, dead-end pieces of the genome. Yet there now appears to be more to it than that. Two groups report in this issue on pseudogenes that can in fact influence gene expression. The mechanism involves pairing of RNA antisense transcripts from pseudogenes with the mRNAs of protein-coding genes, forming a duplex RNA that is processed into endogenous siRNAs.

Suggested Citation

  • Oliver H. Tam & Alexei A. Aravin & Paula Stein & Angelique Girard & Elizabeth P. Murchison & Sihem Cheloufi & Emily Hodges & Martin Anger & Ravi Sachidanandam & Richard M. Schultz & Gregory J. Hannon, 2008. "Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes," Nature, Nature, vol. 453(7194), pages 534-538, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7194:d:10.1038_nature06904
    DOI: 10.1038/nature06904
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    Cited by:

    1. Kami Pekayvaz & Alexander Leunig & Rainer Kaiser & Markus Joppich & Sophia Brambs & Aleksandar Janjic & Oliver Popp & Daniel Nixdorf & Valeria Fumagalli & Nora Schmidt & Vivien Polewka & Afra Anjum & , 2022. "Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Xiaolong Lv & Wen Xiao & Yana Lai & Zhaozhen Zhang & Hongdao Zhang & Chen Qiu & Li Hou & Qin Chen & Duanduan Wang & Yun Gao & Yuanyuan Song & Xinjia Shui & Qinghua Chen & Ruixin Qin & Shuang Liang & W, 2023. "The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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