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Imaging of Rab5 activity identifies essential regulators for phagosome maturation

Author

Listed:
  • Masahiro Kitano

    (Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, and,
    Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita-shi, Osaka 565-0871, Japan)

  • Michio Nakaya

    (Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
    Solution Oriented Research for Science and Technology, Japan Science and Technology Corporation, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Takeshi Nakamura

    (Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, and,)

  • Shigekazu Nagata

    (Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
    Solution Oriented Research for Science and Technology, Japan Science and Technology Corporation, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Michiyuki Matsuda

    (Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, and,)

Abstract

Apoptotic cells are engulfed by phagocytes in a process that involves the GTPase Rab5. This paper shows that Rab5 promotes phagosome maturation, and Rab5 activation is induced by the guanine nucleotide exchange factor Gapex-5, which is recruited to phagosomes via microtubules.

Suggested Citation

  • Masahiro Kitano & Michio Nakaya & Takeshi Nakamura & Shigekazu Nagata & Michiyuki Matsuda, 2008. "Imaging of Rab5 activity identifies essential regulators for phagosome maturation," Nature, Nature, vol. 453(7192), pages 241-245, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7192:d:10.1038_nature06857
    DOI: 10.1038/nature06857
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    Cited by:

    1. Subhankar Kundu & Kaushik Pal & Arghajit Pyne & Xuefeng Wang, 2025. "Force-bearing phagocytic adhesion rings mediate the phagocytosis of surface-bound particles," Nature Communications, Nature, vol. 16(1), pages 1-18, December.

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