IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v452y2008i7190d10.1038_nature06864.html
   My bibliography  Save this article

Lateral presynaptic inhibition mediates gain control in an olfactory circuit

Author

Listed:
  • Shawn R. Olsen

    (Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Rachel I. Wilson

    (Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

Abstract

Olfactory signals are transduced by a large family of odorant receptor proteins, each of which corresponds to a unique glomerulus in the first olfactory relay of the brain. Crosstalk between glomeruli has been proposed to be important in olfactory processing, but it is not clear how these interactions shape the odour responses of second-order neurons. In the Drosophila antennal lobe (a region analogous to the vertebrate olfactory bulb), we selectively removed most interglomerular input to genetically identified second-order olfactory neurons. Here we show that this broadens the odour tuning of these neurons, implying that interglomerular inhibition dominates over interglomerular excitation. The strength of this inhibitory signal scales with total feedforward input to the entire antennal lobe, and has similar tuning in different glomeruli. A substantial portion of this interglomerular inhibition acts at a presynaptic locus, and our results imply that this is mediated by both ionotropic and metabotropic receptors on the same nerve terminal.

Suggested Citation

  • Shawn R. Olsen & Rachel I. Wilson, 2008. "Lateral presynaptic inhibition mediates gain control in an olfactory circuit," Nature, Nature, vol. 452(7190), pages 956-960, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7190:d:10.1038_nature06864
    DOI: 10.1038/nature06864
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06864
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06864?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Inga Petelski & Yannick Günzel & Sercan Sayin & Susanne Kraus & Einat Couzin-Fuchs, 2024. "Synergistic olfactory processing for social plasticity in desert locusts," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Christian Keck & Cristina Savin & Jörg Lücke, 2012. "Feedforward Inhibition and Synaptic Scaling – Two Sides of the Same Coin?," PLOS Computational Biology, Public Library of Science, vol. 8(3), pages 1-15, March.
    3. Eyal Rozenfeld & Merav Tauber & Yair Ben-Chaim & Moshe Parnas, 2021. "GPCR voltage dependence controls neuronal plasticity and behavior," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    4. Jean-Pierre Rospars & Alexandre Grémiaux & David Jarriault & Antoine Chaffiol & Christelle Monsempes & Nina Deisig & Sylvia Anton & Philippe Lucas & Dominique Martinez, 2014. "Heterogeneity and Convergence of Olfactory First-Order Neurons Account for the High Speed and Sensitivity of Second-Order Neurons," PLOS Computational Biology, Public Library of Science, vol. 10(12), pages 1-16, December.
    5. Mami Nakamizo-Dojo & Kenichi Ishii & Jiro Yoshino & Masato Tsuji & Kazuo Emoto, 2023. "Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Yilun Zhang & Tatyana O Sharpee, 2016. "A Robust Feedforward Model of the Olfactory System," PLOS Computational Biology, Public Library of Science, vol. 12(4), pages 1-15, April.
    7. Tyler R. Sizemore & Julius Jonaitis & Andrew M. Dacks, 2023. "Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    8. Eyal Rozenfeld & Nadine Ehmann & Julia E. Manoim & Robert J. Kittel & Moshe Parnas, 2023. "Homeostatic synaptic plasticity rescues neural coding reliability," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:452:y:2008:i:7190:d:10.1038_nature06864. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.