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Crystal structure of the λ repressor and a model for pairwise cooperative operator binding

Author

Listed:
  • Steven Stayrook

    (University of Pennsylvania School of Medicine, 37th and Hamilton Walk, Philadelphia, Pennsylvania 19102-6059, USA)

  • Peera Jaru-Ampornpan

    (University of Pennsylvania School of Medicine, 37th and Hamilton Walk, Philadelphia, Pennsylvania 19102-6059, USA
    Present address: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.)

  • Jenny Ni

    (University of Pennsylvania School of Medicine, 37th and Hamilton Walk, Philadelphia, Pennsylvania 19102-6059, USA)

  • Ann Hochschild

    (Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Mitchell Lewis

    (University of Pennsylvania School of Medicine, 37th and Hamilton Walk, Philadelphia, Pennsylvania 19102-6059, USA)

Abstract

A crystal structure of the intact, dimeric phage λ cI repressor bound to a DNA operator site reveals an unusual architecture allowing the repressor to adopt a conformation that facilitates cooperative binding to adjacent operator sites.

Suggested Citation

  • Steven Stayrook & Peera Jaru-Ampornpan & Jenny Ni & Ann Hochschild & Mitchell Lewis, 2008. "Crystal structure of the λ repressor and a model for pairwise cooperative operator binding," Nature, Nature, vol. 452(7190), pages 1022-1025, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7190:d:10.1038_nature06831
    DOI: 10.1038/nature06831
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    Cited by:

    1. Suparna Sarkar-Banerjee & Sachin Goyal & Ning Gao & John Mack & Benito Thompson & David Dunlap & Krishnananda Chattopadhyay & Laura Finzi, 2018. "Specifically bound lambda repressor dimers promote adjacent non-specific binding," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-19, April.
    2. Reliza J. McGinnis & Chad A. Brambley & Brandon Stamey & William C. Green & Kimberly N. Gragg & Erin R. Cafferty & Thomas C. Terwilliger & Michal Hammel & Thomas J. Hollis & Justin M. Miller & Maria D, 2022. "A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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