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X-ray structure of a prokaryotic pentameric ligand-gated ion channel

Author

Listed:
  • Ricarda J. C. Hilf

    (University of Zürich, Winterthurer Strasse 190, CH-8057 Zürich, Switzerland)

  • Raimund Dutzler

    (University of Zürich, Winterthurer Strasse 190, CH-8057 Zürich, Switzerland)

Abstract

The X-ray structure of a prokaryotic pentameric ligand-gated ion channels (pLGIC) from the bacterium Erwinia chrysanthemi (ELIC) at 3.3 Å resolution is presented. This study reveals the first structure of a pLGIC at high resolution and provides an important model system for the investigation of the general mechanisms of ion permeation and gating within the family.

Suggested Citation

  • Ricarda J. C. Hilf & Raimund Dutzler, 2008. "X-ray structure of a prokaryotic pentameric ligand-gated ion channel," Nature, Nature, vol. 452(7185), pages 375-379, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7185:d:10.1038_nature06717
    DOI: 10.1038/nature06717
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    Cited by:

    1. Nikhil Bharambe & Zhuowen Li & David Seiferth & Asha Manikkoth Balakrishna & Philip C. Biggin & Sandip Basak, 2024. "Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. John T. Petroff & Noah M. Dietzen & Ezry Santiago-McRae & Brett Deng & Maya S. Washington & Lawrence J. Chen & K. Trent Moreland & Zengqin Deng & Michael Rau & James A. J. Fitzpatrick & Peng Yuan & Th, 2022. "Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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