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Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra

Author

Listed:
  • Yu He

    (Department of Chemistry,)

  • Tao Ye

    (Department of Chemistry,)

  • Min Su

    (Purdue University, West Lafayette, Indiana 47907, USA)

  • Chuan Zhang

    (Department of Chemistry,)

  • Alexander E. Ribbe

    (Department of Chemistry,)

  • Wen Jiang

    (Purdue University, West Lafayette, Indiana 47907, USA)

  • Chengde Mao

    (Department of Chemistry,)

Abstract

Supramolecular structures A variety of patterned materials and nanostructures have been made from DNA, by exploiting its programmability to control molecular interactions. But making larger, more complex three-dimensional structures with current fabrication methods would require hundreds of unique DNA strands, an impractical proposition. Help is at hand. A team from Purdue University has developed a modular approach that can be likened to a DNA equivalent of Lego bricks. A few DNA molecules are programmed to fold into a basic structural unit, with four, twenty or sixty copies of that unit then assembling according to reaction conditions into tetrahedra, dodecahedra or buckyballs, respectively. Other complex structures should also be accessible using this strategy.

Suggested Citation

  • Yu He & Tao Ye & Min Su & Chuan Zhang & Alexander E. Ribbe & Wen Jiang & Chengde Mao, 2008. "Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra," Nature, Nature, vol. 452(7184), pages 198-201, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7184:d:10.1038_nature06597
    DOI: 10.1038/nature06597
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    Citations

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    Cited by:

    1. Hui San Ong & Mohd Syafiq Rahim & Mohd Firdaus-Raih & Effirul Ikhwan Ramlan, 2015. "DNA Tetrominoes: The Construction of DNA Nanostructures Using Self-Organised Heterogeneous Deoxyribonucleic Acids Shapes," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-16, August.
    2. Bharath Raj Madhanagopal & Hannah Talbot & Arlin Rodriguez & Jiss Maria Louis & Hana Zeghal & Sweta Vangaveti & Kaalak Reddy & Arun Richard Chandrasekaran, 2024. "The unusual structural properties and potential biological relevance of switchback DNA," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Xiaojun Ding & Jing Chen & Gang Ye, 2024. "Supramolecular polynuclear clusters sustained cubic hydrogen bonded frameworks with octahedral cages for reversible photochromism," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    4. Shivendra Pandey & Daniel Johnson & Ryan Kaplan & Joseph Klobusicky & Govind Menon & David H Gracias, 2014. "Self-Assembly of Mesoscale Isomers: The Role of Pathways and Degrees of Freedom," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-7, October.
    5. Yahong Chen & Chaoyong Yang & Zhi Zhu & Wei Sun, 2022. "Suppressing high-dimensional crystallographic defects for ultra-scaled DNA arrays," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    6. Zhan-Hua Zhao & Bao-Liang Han & Hai-Feng Su & Qi-Lin Guo & Wen-Xin Wang & Jing-Qiu Zhuo & Yong-Nan Guo & Jia-Long Liu & Geng-Geng Luo & Ping Cui & Di Sun, 2024. "Buckling cluster-based H-bonded icosahedral capsules and their propagation to a robust zeolite-like supramolecular framework," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    7. Chi Chen & Xingfei Wei & Molly F. Parsons & Jiajia Guo & James L. Banal & Yinong Zhao & Madelyn N. Scott & Gabriela S. Schlau-Cohen & Rigoberto Hernandez & Mark Bathe, 2022. "Nanoscale 3D spatial addressing and valence control of quantum dots using wireframe DNA origami," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    8. Guang Hu & Wen-Yuan Qiu & Arnout Ceulemans, 2011. "A New Euler's Formula for DNA Polyhedra," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-6, October.

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