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DBC1 is a negative regulator of SIRT1

Author

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  • Ja-Eun Kim

    (Yale University School of Medicine, New Haven, Connecticut 06520, USA)

  • Junjie Chen

    (Yale University School of Medicine, New Haven, Connecticut 06520, USA)

  • Zhenkun Lou

    (Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA)

Abstract

Linking ageing and cancer The deacetylase SIRT1, the mammalian version of the Sir2 protein that plays a critical role in determining lifespan in yeast, has been implicated in various cellular functions and possibly in tumorigenesis and ageing. The factors regulating SIRT1 are not well known but two groups now report that the tumour suppressor DBC1 is a negative regulator of SIRT1. By inhibiting SIRT1, DBC1 promotes increased acetylation of the tumour suppressor p53 and p53-mediated apoptosis in human cells.

Suggested Citation

  • Ja-Eun Kim & Junjie Chen & Zhenkun Lou, 2008. "DBC1 is a negative regulator of SIRT1," Nature, Nature, vol. 451(7178), pages 583-586, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7178:d:10.1038_nature06500
    DOI: 10.1038/nature06500
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    Cited by:

    1. Evangelia Petsalaki & Alexander Stark & Eduardo García-Urdiales & Robert B Russell, 2009. "Accurate Prediction of Peptide Binding Sites on Protein Surfaces," PLOS Computational Biology, Public Library of Science, vol. 5(3), pages 1-10, March.

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