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Neurite arborization and mosaic spacing in the mouse retina require DSCAM

Author

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  • Peter G. Fuerst

    (The Jackson Laboratory, Bar Harbor, Maine 04609, USA)

  • Amane Koizumi

    (Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Present address: National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, 444-8585, Japan.)

  • Richard H. Masland

    (Massachusetts General Hospital, Boston, Massachusetts 02114, USA)

  • Robert W. Burgess

    (The Jackson Laboratory, Bar Harbor, Maine 04609, USA)

Abstract

Making connections Downs syndrome cell adhesion molecules (Dscams) are adhesion molecules of the immunoglolulin superfamily. Drosophila Dscams have been implicated in the organization of neural connectivity, but little is known about the functions of the closely related molecules in vertebrates. Masahito Yamagata and Joshua Sanes now demonstrate a role for Dscam and DscamL in patterning of lamina-specific connections in the chick retina. Two other adhesion molecules, called Sidekick-1 and Sidekick-2, act in a similar way. These molecules are widely distributed in the nervous system and may be part of an 'adhesive code' that patterns neural connections in the brain. Further evidence for the importance of Dscams in vertebrate neural patterning comes from Fuerst et al., who identify a role for DSCAM in establishing neural circuits in the retina of mice.

Suggested Citation

  • Peter G. Fuerst & Amane Koizumi & Richard H. Masland & Robert W. Burgess, 2008. "Neurite arborization and mosaic spacing in the mouse retina require DSCAM," Nature, Nature, vol. 451(7177), pages 470-474, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7177:d:10.1038_nature06514
    DOI: 10.1038/nature06514
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    Cited by:

    1. Ken-ichi Dewa & Nariko Arimura & Wataru Kakegawa & Masayuki Itoh & Toma Adachi & Satoshi Miyashita & Yukiko U. Inoue & Kento Hizawa & Kei Hori & Natsumi Honjoya & Haruya Yagishita & Shinichiro Taya & , 2024. "Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Julian M L Budd & Krisztina Kovács & Alex S Ferecskó & Péter Buzás & Ulf T Eysel & Zoltán F Kisvárday, 2010. "Neocortical Axon Arbors Trade-off Material and Conduction Delay Conservation," PLOS Computational Biology, Public Library of Science, vol. 6(3), pages 1-25, March.
    3. Kiya W. Govek & Patrick Nicodemus & Yuxuan Lin & Jake Crawford & Artur B. Saturnino & Hannah Cui & Kristi Zoga & Michael P. Hart & Pablo G. Camara, 2023. "CAJAL enables analysis and integration of single-cell morphological data using metric geometry," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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