IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v451y2008i7176d10.1038_nature06494.html
   My bibliography  Save this article

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Author

Listed:
  • Benjamin L. Ebert

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Jennifer Pretz

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • Jocelyn Bosco

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • Cindy Y. Chang

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • Pablo Tamayo

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • Naomi Galili

    (University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA)

  • Azra Raza

    (University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA)

  • David E. Root

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA)

  • Eyal Attar

    (Massachusetts General Hospital, Boston, Massachusetts 02114, USA)

  • Steven R. Ellis

    (University of Louisville)

  • Todd R. Golub

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA)

Abstract

Deletions on chromososme 5q are associated with myelodysplastic lesions. The genes responsible have largely remained elusive. But use of an RNA interference-based approach that can identify haploinsufficient tumour suppressor genes identifies RPS14, which regulates ribosomal RNA processing as a candidate tumour suppressor gene responsible for this so-called 5q− syndrome.

Suggested Citation

  • Benjamin L. Ebert & Jennifer Pretz & Jocelyn Bosco & Cindy Y. Chang & Pablo Tamayo & Naomi Galili & Azra Raza & David E. Root & Eyal Attar & Steven R. Ellis & Todd R. Golub, 2008. "Identification of RPS14 as a 5q- syndrome gene by RNA interference screen," Nature, Nature, vol. 451(7176), pages 335-339, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7176:d:10.1038_nature06494
    DOI: 10.1038/nature06494
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06494
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06494?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Guillermo Serrano & Nerea Berastegui & Aintzane Díaz-Mazkiaran & Paula García-Olloqui & Carmen Rodriguez-Res & Sofia Huerga-Dominguez & Marina Ainciburu & Amaia Vilas-Zornoza & Patxi San Martin-Uriz &, 2024. "Single-cell transcriptional profile of CD34+ hematopoietic progenitor cells from del(5q) myelodysplastic syndromes and impact of lenalidomide," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Kiran N Meekings & Jeremy Leipzig & Frederic D Bushman & Graham P Taylor & Charles R M Bangham, 2008. "HTLV-1 Integration into Transcriptionally Active Genomic Regions Is Associated with Proviral Expression and with HAM/TSP," PLOS Pathogens, Public Library of Science, vol. 4(3), pages 1-10, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:451:y:2008:i:7176:d:10.1038_nature06494. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.