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Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

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  • Antonina Roll-Mecak

    (University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA)

  • Ronald D. Vale

    (University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA)

Abstract

Spastin structure revealed Spastin, a microtubule severing protein involved in the assembly or function of nuclear protein complexes, has attracted interest because of its role in neuronal synapse formation, and the discovery that mutations in the gene cause hereditary neurodegenerative disease. The structure of spastin has now been determined to atomic resolution by X-ray crystallography, revealing an AAA ATPase cassette augmented by structural elements unique to the microtubule severing enzyme subfamily. Mapping of hereditary spastic paraplegia mutations onto the structure of spastin reveals how disease mutations damage the enzyme.

Suggested Citation

  • Antonina Roll-Mecak & Ronald D. Vale, 2008. "Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin," Nature, Nature, vol. 451(7176), pages 363-367, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7176:d:10.1038_nature06482
    DOI: 10.1038/nature06482
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    Cited by:

    1. Yang-Nim Park & David Morales & Emily H Rubinson & Daniel Masison & Evan Eisenberg & Lois E Greene, 2012. "Differences in the Curing of [PSI+] Prion by Various Methods of Hsp104 Inactivation," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-15, June.
    2. Doan Tuong-Van Le & Thomas Eckert & Günther Woehlke, 2013. "Computer Simulation of Assembly and Co-operativity of Hexameric AAA ATPases," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-19, July.
    3. Yin-Wei Kuo & Mohammed Mahamdeh & Yazgan Tuna & Jonathon Howard, 2022. "The force required to remove tubulin from the microtubule lattice by pulling on its α-tubulin C-terminal tail," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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