IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v451y2008i7175d10.1038_nature06487.html
   My bibliography  Save this article

Endogenous human microRNAs that suppress breast cancer metastasis

Author

Listed:
  • Sohail F. Tavazoie

    (Cancer Biology and Genetics Program,
    Department of Medicine,)

  • Claudio Alarcón

    (Cancer Biology and Genetics Program,)

  • Thordur Oskarsson

    (Cancer Biology and Genetics Program,)

  • David Padua

    (Cancer Biology and Genetics Program,)

  • Qiongqing Wang

    (Cancer Biology and Genetics Program,)

  • Paula D. Bos

    (Cancer Biology and Genetics Program,)

  • William L. Gerald

    (Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA)

  • Joan Massagué

    (Cancer Biology and Genetics Program,)

Abstract

A search for general regulators of cancer metastasis has yielded a set of microRNAs for which expression is specifically lost as human breast cancer cells develop metastatic potential. Here we show that restoring the expression of these microRNAs in malignant cells suppresses lung and bone metastasis by human cancer cells in vivo. Of these microRNAs, miR-126 restoration reduces overall tumour growth and proliferation, whereas miR-335 inhibits metastatic cell invasion. miR-335 regulates a set of genes whose collective expression in a large cohort of human tumours is associated with risk of distal metastasis. miR-335 suppresses metastasis and migration through targeting of the progenitor cell transcription factor SOX4 and extracellular matrix component tenascin C. Expression of miR-126 and miR-335 is lost in the majority of primary breast tumours from patients who relapse, and the loss of expression of either microRNA is associated with poor distal metastasis-free survival. miR-335 and miR-126 are thus identified as metastasis suppressor microRNAs in human breast cancer.

Suggested Citation

  • Sohail F. Tavazoie & Claudio Alarcón & Thordur Oskarsson & David Padua & Qiongqing Wang & Paula D. Bos & William L. Gerald & Joan Massagué, 2008. "Endogenous human microRNAs that suppress breast cancer metastasis," Nature, Nature, vol. 451(7175), pages 147-152, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7175:d:10.1038_nature06487
    DOI: 10.1038/nature06487
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06487
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06487?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Urmo Võsa & Tõnu Esko & Silva Kasela & Tarmo Annilo, 2015. "Altered Gene Expression Associated with microRNA Binding Site Polymorphisms," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-24, October.
    2. Agius Phaedra & Ying Yiming & Campbell Colin, 2009. "Bayesian Unsupervised Learning with Multiple Data Types," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 8(1), pages 1-29, June.
    3. Fabricio F Costa & Jared M Bischof & Elio F Vanin & Rishi R Lulla & Min Wang & Simone T Sredni & Veena Rajaram & Maria de Fátima Bonaldo & Deli Wang & Stewart Goldman & Tadanori Tomita & Marcelo B Soa, 2011. "Identification of MicroRNAs as Potential Prognostic Markers in Ependymoma," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-10, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:451:y:2008:i:7175:d:10.1038_nature06487. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.