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Visualizing spatially correlated dynamics that directs RNA conformational transitions

Author

Listed:
  • Qi Zhang

    (University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA)

  • Andrew C. Stelzer

    (University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA)

  • Charles K. Fisher

    (University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA)

  • Hashim M. Al-Hashimi

    (University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA)

Abstract

This paper reports an NMR approach that enables the three-dimensional movement of two linked RNA helices to be followed for a period up to milliseconds. The two helices move in a highly correlated manner, demonstrating both twisting and bending. Results with different liganded conformations demonstrate that the motions of the unstructured RNA maps out positions within the dynamic envelope described by the bound structures.

Suggested Citation

  • Qi Zhang & Andrew C. Stelzer & Charles K. Fisher & Hashim M. Al-Hashimi, 2007. "Visualizing spatially correlated dynamics that directs RNA conformational transitions," Nature, Nature, vol. 450(7173), pages 1263-1267, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7173:d:10.1038_nature06389
    DOI: 10.1038/nature06389
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    Cited by:

    1. Yanyan Xue & Jun Li & Dian Chen & Xizhu Zhao & Liang Hong & Yu Liu, 2023. "Observation of structural switch in nascent SAM-VI riboswitch during transcription at single-nucleotide and single-molecule resolution," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Gregory D Friedland & Nils-Alexander Lakomek & Christian Griesinger & Jens Meiler & Tanja Kortemme, 2009. "A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family," PLOS Computational Biology, Public Library of Science, vol. 5(5), pages 1-16, May.
    3. Ainan Geng & Laura Ganser & Rohit Roy & Honglue Shi & Supriya Pratihar & David A. Case & Hashim M. Al-Hashimi, 2023. "An RNA excited conformational state at atomic resolution," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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