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The molecular sociology of the cell

Author

Listed:
  • Carol V. Robinson

    (Department of Chemistry
    University of Cambridge)

  • Andrej Sali

    (and California Institute for Quantitative Biosciences, Byers Hall, Suite 503B, University of California at San Francisco)

  • Wolfgang Baumeister

    (Max Planck Institute of Biochemistry)

Abstract

Proteomic studies have yielded detailed lists of the proteins present in a cell. Comparatively little is known, however, about how these proteins interact and are spatially arranged within the 'functional modules' of the cell: that is, the 'molecular sociology' of the cell. This gap is now being bridged by using emerging experimental techniques, such as mass spectrometry of complexes and single-particle cryo-electron microscopy, to complement traditional biochemical and biophysical methods. With the development of integrative computational methods to exploit the data obtained, such hybrid approaches will uncover the molecular architectures, and perhaps even atomic models, of many protein complexes. With these structures in hand, researchers will be poised to use cryo-electron tomography to view protein complexes in action within cells, providing unprecedented insights into protein-interaction networks.

Suggested Citation

  • Carol V. Robinson & Andrej Sali & Wolfgang Baumeister, 2007. "The molecular sociology of the cell," Nature, Nature, vol. 450(7172), pages 973-982, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7172:d:10.1038_nature06523
    DOI: 10.1038/nature06523
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    Cited by:

    1. Akira R Kinjo & Haruki Nakamura, 2012. "Composite Structural Motifs of Binding Sites for Delineating Biological Functions of Proteins," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-11, February.
    2. Lucien F. Krapp & Luciano A. Abriata & Fabio Cortés Rodriguez & Matteo Dal Peraro, 2023. "PeSTo: parameter-free geometric deep learning for accurate prediction of protein binding interfaces," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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