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A viral microRNA functions as an orthologue of cellular miR-155

Author

Listed:
  • Eva Gottwein

    (Department of Molecular Genetics and Microbiology,)

  • Neelanjan Mukherjee

    (University Program in Genetics and Genomics,)

  • Christoph Sachse

    (Cenix BioScience GmbH, Tatzberg 47, 01307 Dresden, Germany)

  • Corina Frenzel

    (Cenix BioScience GmbH, Tatzberg 47, 01307 Dresden, Germany)

  • William H. Majoros

    (Institute for Genome Sciences and Policy,)

  • Jen-Tsan A. Chi

    (Department of Molecular Genetics and Microbiology,
    Institute for Genome Sciences and Policy,)

  • Ravi Braich

    (Alnylam Pharmaceuticals, Inc., 300 3rd Street, Cambridge, Massachusetts 02142, USA)

  • Muthiah Manoharan

    (Alnylam Pharmaceuticals, Inc., 300 3rd Street, Cambridge, Massachusetts 02142, USA)

  • Jürgen Soutschek

    (Alnylam Pharmaceuticals, Inc., 300 3rd Street, Cambridge, Massachusetts 02142, USA)

  • Uwe Ohler

    (Duke University Medical Center, Durham, North Carolina 27710, USA
    Institute for Genome Sciences and Policy,
    Duke University, Durham, North Carolina 27708, USA)

  • Bryan R. Cullen

    (Department of Molecular Genetics and Microbiology,)

Abstract

RNA copied Some viral microRNAs are known to bind host cell mRNAs to block translation or induce their degradation. Now a microRNA from the herpes virus associated with Kaposi's sarcoma has been found to mimic the ubiquitous cellular microRNA, miR-155. The viral version of this RNA, which shows significant homology to the real thing, may have evolved to exploit an existing gene regulatory pathway in host B cells.

Suggested Citation

  • Eva Gottwein & Neelanjan Mukherjee & Christoph Sachse & Corina Frenzel & William H. Majoros & Jen-Tsan A. Chi & Ravi Braich & Muthiah Manoharan & Jürgen Soutschek & Uwe Ohler & Bryan R. Cullen, 2007. "A viral microRNA functions as an orthologue of cellular miR-155," Nature, Nature, vol. 450(7172), pages 1096-1099, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7172:d:10.1038_nature05992
    DOI: 10.1038/nature05992
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    Cited by:

    1. Parawee Lekprasert & Michael Mayhew & Uwe Ohler, 2011. "Assessing the Utility of Thermodynamic Features for microRNA Target Prediction under Relaxed Seed and No Conservation Requirements," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-13, June.

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