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Neural substrates of awakening probed with optogenetic control of hypocretin neurons

Author

Listed:
  • Antoine R. Adamantidis

    (Stanford University, 701B Welch Road, Palo Alto, California 94304, USA)

  • Feng Zhang

    (Stanford University, James H. Clark Center W083, Stanford, California 94305, USA)

  • Alexander M. Aravanis

    (Stanford University, James H. Clark Center W083, Stanford, California 94305, USA)

  • Karl Deisseroth

    (Stanford University, 701B Welch Road, Palo Alto, California 94304, USA
    Stanford University, James H. Clark Center W083, Stanford, California 94305, USA)

  • Luis de Lecea

    (Stanford University, 701B Welch Road, Palo Alto, California 94304, USA)

Abstract

Sleepers awake A paper published in Nature in April raised the intriguing possibility that optical therapies might be developed to treat neurological disorders. That work, in tissue slices and in C. elegans roundworms, showed that brain cells can be genetically engineered to alter their activity in response to pulses of different colours of light. A follow-up study now shows that behaviour can be modified in a living mammal by similar means. Hypocretin (Hcrt)-producing neurons in the hypothalamus are active during transitions from sleep to waking states. Optical stimulation of mouse Hcrt neurons engineered to respond to light increases the likelihood of transition from sleep to wakefulness, with higher frequencies causing more abrupt awakening. As Hcrt deficiency is linked to narcolepsy, these results may provide insights into sleep disorders.

Suggested Citation

  • Antoine R. Adamantidis & Feng Zhang & Alexander M. Aravanis & Karl Deisseroth & Luis de Lecea, 2007. "Neural substrates of awakening probed with optogenetic control of hypocretin neurons," Nature, Nature, vol. 450(7168), pages 420-424, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7168:d:10.1038_nature06310
    DOI: 10.1038/nature06310
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    Cited by:

    1. Han-Tao Li & Paulius Viskaitis & Eva Bracey & Daria Peleg-Raibstein & Denis Burdakov, 2024. "Transient targeting of hypothalamic orexin neurons alleviates seizures in a mouse model of epilepsy," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Kei Kimura & Yuji Nagai & Gaku Hatanaka & Yang Fang & Soshi Tanabe & Andi Zheng & Maki Fujiwara & Mayuko Nakano & Yukiko Hori & Ryosuke F. Takeuchi & Mikio Inagaki & Takafumi Minamimoto & Ichiro Fujit, 2023. "A mosaic adeno-associated virus vector as a versatile tool that exhibits high levels of transgene expression and neuron specificity in primate brain," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Olivia Macovei, 2020. "Conceptual Delimitations related to the Philosophical Approaches on Synthetic Biology," Logos Universalitate Mentalitate Educatie Noutate - Sectiunea Filosofie si Stiinte umaniste/ Logos Universality Mentality Education Novelty - Section: Philosophy and Humanistic Sciences, Editura Lumen, Department of Economics, vol. 8(2), pages 83-104, December.
    4. Shuancheng Ren & Cai Zhang & Faguo Yue & Jinxiang Tang & Wei Zhang & Yue Zheng & Yuanyuan Fang & Na Wang & Zhenbo Song & Zehui Zhang & Xiaolong Zhang & Han Qin & Yaling Wang & Jianxia Xia & Chenggang , 2024. "A midbrain GABAergic circuit constrains wakefulness in a mouse model of stress," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    5. Matthew G. Clark & Gil A. Gonzalez & Yiyang Luo & Jesus A. Aldana-Mendoza & Mark S. Carlsen & Gregory Eakins & Mingji Dai & Chi Zhang, 2022. "Real-time precision opto-control of chemical processes in live cells," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    6. Ya-Nan Zhao & Jian-Bo Jiang & Shi-Yuan Tao & Yang Zhang & Ze-Ka Chen & Wei-Min Qu & Zhi-Li Huang & Su-Rong Yang, 2022. "GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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