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SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

Author

Listed:
  • Kristen Jepsen

    (Howard Hughes Medical Institute)

  • Derek Solum

    (Howard Hughes Medical Institute)

  • Tianyuan Zhou

    (Howard Hughes Medical Institute)

  • Robert J. McEvilly

    (Howard Hughes Medical Institute)

  • Hyun-Jung Kim

    (Howard Hughes Medical Institute)

  • Christopher K. Glass

    (University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Ola Hermanson

    (Center of Excellence in Developmental Biology (CEDB/DBRM), Organic Bioelectronics (OBOE), Karolinska Institutet)

  • Michael G. Rosenfeld

    (Howard Hughes Medical Institute)

Abstract

The SMRT transcriptional co-repressor is shown to have a crucial role in forebrain development and in maintaining neural stem cells, and it represses expression of a histone H3 trimethyl K27 demethylase, which can activate components of the neurogenic programme.

Suggested Citation

  • Kristen Jepsen & Derek Solum & Tianyuan Zhou & Robert J. McEvilly & Hyun-Jung Kim & Christopher K. Glass & Ola Hermanson & Michael G. Rosenfeld, 2007. "SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron," Nature, Nature, vol. 450(7168), pages 415-419, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7168:d:10.1038_nature06270
    DOI: 10.1038/nature06270
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    Cited by:

    1. Wenxian Wang & Hyeyoung Cho & Jae W. Lee & Soo-Kyung Lee, 2022. "The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Andreas Lackner & Michael Müller & Magdalena Gamperl & Delyana Stoeva & Olivia Langmann & Henrieta Papuchova & Elisabeth Roitinger & Gerhard Dürnberger & Richard Imre & Karl Mechtler & Paulina A. Lato, 2023. "The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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