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Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling

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  • Oliver Daumke

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK
    Present addresses: Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Str. 10, 13092 Berlin, Germany (O.D.); Umeå University, Department of Medical Biochemistry and Biophysics, 90187 Umeå, Sweden (R.L.).)

  • Richard Lundmark

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK
    Present addresses: Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Str. 10, 13092 Berlin, Germany (O.D.); Umeå University, Department of Medical Biochemistry and Biophysics, 90187 Umeå, Sweden (R.L.).)

  • Yvonne Vallis

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK)

  • Sascha Martens

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK)

  • P. Jonathan G. Butler

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK)

  • Harvey T. McMahon

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK)

Abstract

Structural details of mouse EHD2 are provided along with in vitro and in vivo assays, showing how an EHD oligomer is formed and how perpendicular curvature stresses on a membrane surface can result in remodelling of membranes by EHD oligomeric rings. The functional implications of the EHD2 structure for understanding of membrane deformation are also discussed.

Suggested Citation

  • Oliver Daumke & Richard Lundmark & Yvonne Vallis & Sascha Martens & P. Jonathan G. Butler & Harvey T. McMahon, 2007. "Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling," Nature, Nature, vol. 449(7164), pages 923-927, October.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7164:d:10.1038_nature06173
    DOI: 10.1038/nature06173
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    Cited by:

    1. Alan K. Okada & Kazuki Teranishi & Mark R. Ambroso & Jose Mario Isas & Elena Vazquez-Sarandeses & Joo-Yeun Lee & Arthur Alves Melo & Priyatama Pandey & Daniel Merken & Leona Berndt & Michael Lammers &, 2021. "Lysine acetylation regulates the interaction between proteins and membranes," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Arthur A. Melo & Thiemo Sprink & Jeffrey K. Noel & Elena Vázquez-Sarandeses & Chris Hoorn & Saif Mohd & Justus Loerke & Christian M. T. Spahn & Oliver Daumke, 2022. "Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Viola Nähse & Camilla Raiborg & Kia Wee Tan & Sissel Mørk & Maria Lyngaas Torgersen & Eva Maria Wenzel & Mireia Nager & Veijo T. Salo & Terje Johansen & Elina Ikonen & Kay Oliver Schink & Harald Stenm, 2023. "ATPase activity of DFCP1 controls selective autophagy," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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