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Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors

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  • César Cobaleda

    (Research Institute of Molecular Pathology, Vienna Biocenter, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Present address: Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.)

  • Wolfram Jochum

    (University Hospital, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland)

  • Meinrad Busslinger

    (Research Institute of Molecular Pathology, Vienna Biocenter, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria)

Abstract

Differentiation reversed How the identity of mature, differentiated cell types is controlled and what degree of developmental plasticity can still be realized by fully differentiated cell types is an important and fundamental question in developmental biology and stem cell research. A central question in this field, that of whether cells are reprogrammed directly to a different cell type — by direct transdifferentiation — or take a backward step to a more immature state before moving along another pathway — called dedifferentiation — is answered by a report in this issue. Cobaleda et al. demonstrate dedifferentiation during the conversion of mature B lymphoid cells to functional T cells. Deletion of Pax5, a transcription factor important for B cell differentiation and function, caused mature B cells to dedifferentiate into progenitor cells that can give rise to T cells. Pax5 is also known to play a role in cancer, and its loss is shown to induce lymphomas that arise from progenitor cells.

Suggested Citation

  • César Cobaleda & Wolfram Jochum & Meinrad Busslinger, 2007. "Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors," Nature, Nature, vol. 449(7161), pages 473-477, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7161:d:10.1038_nature06159
    DOI: 10.1038/nature06159
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    Cited by:

    1. Qiang Shan & Xiang Li & Xia Chen & Zhouhao Zeng & Shaoqi Zhu & Kexin Gai & Weiqun Peng & Hai-Hui Xue, 2021. "Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture," Nature Communications, Nature, vol. 12(1), pages 1-20, December.
    2. Marta Isidro-Hernández & Ana Casado-García & Ninad Oak & Silvia Alemán-Arteaga & Belén Ruiz-Corzo & Jorge Martínez-Cano & Andrea Mayado & Elena G. Sánchez & Oscar Blanco & Ma Luisa Gaspar & Alberto Or, 2023. "Immune stress suppresses innate immune signaling in preleukemic precursor B-cells to provoke leukemia in predisposed mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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