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IgH class switching and translocations use a robust non-classical end-joining pathway

Author

Listed:
  • Catherine T. Yan

    (Howard Hughes Medical Institute,
    The Children’s Hospital,
    Immune Disease Institute,
    Department of Genetics,)

  • Cristian Boboila

    (Howard Hughes Medical Institute,
    The Children’s Hospital,
    Immune Disease Institute,
    Department of Genetics,)

  • Ellen Kris Souza

    (Howard Hughes Medical Institute,
    The Children’s Hospital,
    Immune Disease Institute,
    Department of Genetics,)

  • Sonia Franco

    (Howard Hughes Medical Institute,
    The Children’s Hospital,
    Immune Disease Institute,
    Department of Genetics,)

  • Thomas R. Hickernell

    (Howard Hughes Medical Institute,
    The Children’s Hospital,
    Immune Disease Institute,
    Department of Genetics,)

  • Michael Murphy

    (Howard Hughes Medical Institute,
    The Children’s Hospital,
    Immune Disease Institute,
    Department of Genetics,)

  • Sunil Gumaste

    (Howard Hughes Medical Institute,
    The Children’s Hospital,
    Immune Disease Institute,
    Department of Genetics,)

  • Mark Geyer

    (The Children’s Hospital,)

  • Ali A. Zarrin

    (Howard Hughes Medical Institute,
    The Children’s Hospital,
    Immune Disease Institute,
    Department of Genetics,)

  • John P. Manis

    (The Children’s Hospital,
    Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Klaus Rajewsky

    (Immune Disease Institute,
    Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Frederick W. Alt

    (Howard Hughes Medical Institute,
    The Children’s Hospital,
    Immune Disease Institute,
    Department of Genetics,)

Abstract

Programmed DNA breaks are made and repaired at two points during the development of antibody-producing B cells. While the breaks occurring during V(D)J recombination utilize factors that promote non-homologous end joining, this study finds that breaks that happen during class switch recombination require only a subset of these factors, suggesting that there are other as-yet-unrecognized proteins that function in this process.

Suggested Citation

  • Catherine T. Yan & Cristian Boboila & Ellen Kris Souza & Sonia Franco & Thomas R. Hickernell & Michael Murphy & Sunil Gumaste & Mark Geyer & Ali A. Zarrin & John P. Manis & Klaus Rajewsky & Frederick , 2007. "IgH class switching and translocations use a robust non-classical end-joining pathway," Nature, Nature, vol. 449(7161), pages 478-482, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7161:d:10.1038_nature06020
    DOI: 10.1038/nature06020
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    Cited by:

    1. Demis Menolfi & Brian J. Lee & Hanwen Zhang & Wenxia Jiang & Nicole E. Bowen & Yunyue Wang & Junfei Zhao & Antony Holmes & Steven Gershik & Raul Rabadan & Baek Kim & Shan Zha, 2023. "ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Estelle Vincendeau & Wenming Wei & Xuefei Zhang & Cyril Planchais & Wei Yu & Hélène Lenden-Hasse & Thomas Cokelaer & Juliana Pipoli da Fonseca & Hugo Mouquet & David J. Adams & Frederick W. Alt & Step, 2022. "SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Yijiang Xu & Hang Zhou & Ginell Post & Hong Zan & Paolo Casali, 2022. "Rad52 mediates class-switch DNA recombination to IgD," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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