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Integrating molecular and network biology to decode endocytosis

Author

Listed:
  • Eva M. Schmid

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Harvey T. McMahon

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

Abstract

Inside story The strength of network biology lies in its ability to derive cell biological information without a priori mechanistic or molecular knowledge. Eva Schmid and Harvey McMahon show that a molecular understanding of clathrin-mediated endocytosis, a process used by eukaryotic cells to pack nutrients and other molecules into vesicles for internalization, can refine the network approach and allow the derivation of general biological principles.

Suggested Citation

  • Eva M. Schmid & Harvey T. McMahon, 2007. "Integrating molecular and network biology to decode endocytosis," Nature, Nature, vol. 448(7156), pages 883-888, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7156:d:10.1038_nature06031
    DOI: 10.1038/nature06031
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    Cited by:

    1. Anmin Jiang & Kye Kudo & Rachel S. Gormal & Sevannah Ellis & Sikao Guo & Tristan P. Wallis & Shanley F. Longfield & Phillip J. Robinson & Margaret E. Johnson & Merja Joensuu & Frédéric A. Meunier, 2024. "Dynamin1 long- and short-tail isoforms exploit distinct recruitment and spatial patterns to form endocytic nanoclusters," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Dinah Loerke & Marcel Mettlen & Defne Yarar & Khuloud Jaqaman & Henry Jaqaman & Gaudenz Danuser & Sandra L Schmid, 2009. "Cargo and Dynamin Regulate Clathrin-Coated Pit Maturation," PLOS Biology, Public Library of Science, vol. 7(3), pages 1-12, March.

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