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LKB1 modulates lung cancer differentiation and metastasis

Author

Listed:
  • Hongbin Ji

    (Dana-Farber Cancer Institute
    Ludwig Center at Dana-Farber/Harvard Cancer Center,)

  • Matthew R. Ramsey

    (Department of Genetics,
    Curriculum in Genetics and Molecular Biology, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA)

  • D. Neil Hayes

    (Department of Medicine,)

  • Cheng Fan

    (Department of Genetics,)

  • Kate McNamara

    (Dana-Farber Cancer Institute
    Ludwig Center at Dana-Farber/Harvard Cancer Center,)

  • Piotr Kozlowski

    (Division of Translational Medicine,)

  • Chad Torrice

    (Department of Medicine,)

  • Michael C. Wu

    (Harvard School of Public Health)

  • Takeshi Shimamura

    (Dana-Farber Cancer Institute)

  • Samanthi A. Perera

    (Dana-Farber Cancer Institute
    Ludwig Center at Dana-Farber/Harvard Cancer Center,)

  • Mei-Chih Liang

    (Dana-Farber Cancer Institute
    Ludwig Center at Dana-Farber/Harvard Cancer Center,)

  • Dongpo Cai

    (Dana-Farber Cancer Institute)

  • George N. Naumov

    (Children’s Hospital)

  • Lei Bao

    (University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA)

  • Cristina M. Contreras

    (University of Texas Southwestern Medical Center, Dallas, Texas 75390-9072, USA)

  • Danan Li

    (Dana-Farber Cancer Institute
    Ludwig Center at Dana-Farber/Harvard Cancer Center,)

  • Liang Chen

    (Dana-Farber Cancer Institute
    Ludwig Center at Dana-Farber/Harvard Cancer Center,)

  • Janakiraman Krishnamurthy

    (Department of Genetics,
    Department of Medicine,)

  • Jussi Koivunen

    (Dana-Farber Cancer Institute)

  • Lucian R. Chirieac

    (Department of Pathology,)

  • Robert F. Padera

    (Department of Pathology,)

  • Roderick T. Bronson

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Neal I. Lindeman

    (Department of Pathology,)

  • David C. Christiani

    (Department of Environmental Health,)

  • Xihong Lin

    (Harvard School of Public Health)

  • Geoffrey I. Shapiro

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital)

  • Pasi A. Jänne

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital)

  • Bruce E. Johnson

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital)

  • Matthew Meyerson

    (Dana-Farber Cancer Institute
    Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA)

  • David J. Kwiatkowski

    (Division of Translational Medicine,)

  • Diego H. Castrillon

    (University of Texas Southwestern Medical Center, Dallas, Texas 75390-9072, USA)

  • Nabeel Bardeesy

    (Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA)

  • Norman E. Sharpless

    (Department of Genetics,
    Department of Medicine,
    Curriculum in Genetics and Molecular Biology, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA)

  • Kwok-Kin Wong

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital)

Abstract

Lkb1 and cancer causation Mutations in the Lkb1 tumour suppressor gene are found in Peutz–Jeghers syndrome patients who have an increased incidence of cancers. Now Lkb1 mutations have been found in the squamous carcinoma subtype of non-small-cell lung cancers. In a mouse model for lung cancer in which Lkb1 loss is combined with K-Ras mutations, more aggressive tumours arise than with K-Ras mutations alone and often these are classified as squamous and large-cell carcinomas. Thus loss of Lkb1 modulates lung cancer differentiation, and Lkb1 loss may be a useful marker for predicting disease development and spread. The pathways regulated by LKB1 represent possible therapeutic targets.

Suggested Citation

  • Hongbin Ji & Matthew R. Ramsey & D. Neil Hayes & Cheng Fan & Kate McNamara & Piotr Kozlowski & Chad Torrice & Michael C. Wu & Takeshi Shimamura & Samanthi A. Perera & Mei-Chih Liang & Dongpo Cai & Geo, 2007. "LKB1 modulates lung cancer differentiation and metastasis," Nature, Nature, vol. 448(7155), pages 807-810, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7155:d:10.1038_nature06030
    DOI: 10.1038/nature06030
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    Cited by:

    1. Zhiyuan Cheng & Ning Cheng & Dian Shi & Xiaoyu Ren & Ting Gan & Yana Bai & Kehu Yang, 2019. "The Relationship between Nkx2.1 and DNA Oxidative Damage Repair in Nickel Smelting Workers: Jinchang Cohort Study," IJERPH, MDPI, vol. 16(1), pages 1-15, January.
    2. Biaobin Jiang & Quanhua Mu & Fufang Qiu & Xuefeng Li & Weiqi Xu & Jun Yu & Weilun Fu & Yong Cao & Jiguang Wang, 2021. "Machine learning of genomic features in organotropic metastases stratifies progression risk of primary tumors," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    3. Christopher W. Murray & Jennifer J. Brady & Mingqi Han & Hongchen Cai & Min K. Tsai & Sarah E. Pierce & Ran Cheng & Janos Demeter & David M. Feldser & Peter K. Jackson & David B. Shackelford & Monte M, 2022. "LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Wenbin Xu & Han Yao & Zhen Wu & Xiaojun Yan & Zishan Jiao & Yajing Liu & Meng Zhang & Donglai Wang, 2024. "Oncoprotein SET-associated transcription factor ZBTB11 triggers lung cancer metastasis," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    5. Andre Lima Queiroz & Ezequiel Dantas & Shakti Ramsamooj & Anirudh Murthy & Mujmmail Ahmed & Elizabeth R. M. Zunica & Roger J. Liang & Jessica Murphy & Corey D. Holman & Curtis J. Bare & Gregory Ghahra, 2022. "Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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