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The Relationship between Nkx2.1 and DNA Oxidative Damage Repair in Nickel Smelting Workers: Jinchang Cohort Study

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  • Zhiyuan Cheng

    (Evidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
    School of Public Health, Department of Epidemiology and Statistics, Lanzhou University, Lanzhou 730000, China)

  • Ning Cheng

    (Centre of Medical Laboratory, School of Basic Medical Science, Lanzhou University, Lanzhou 730000, China)

  • Dian Shi

    (School of Public Health, Department of Epidemiology and Statistics, Lanzhou University, Lanzhou 730000, China)

  • Xiaoyu Ren

    (School of Public Health, Department of Epidemiology and Statistics, Lanzhou University, Lanzhou 730000, China)

  • Ting Gan

    (School of Public Health, Department of Epidemiology and Statistics, Lanzhou University, Lanzhou 730000, China)

  • Yana Bai

    (School of Public Health, Department of Epidemiology and Statistics, Lanzhou University, Lanzhou 730000, China)

  • Kehu Yang

    (Evidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China)

Abstract

Background : Occupational nickel exposure can cause DNA oxidative damage and influence DNA repair. However, the underlying mechanism of nickel-induced high-risk of lung cancer has not been fully understood. Our study aims to evaluate whether the nickel-induced oxidative damage and DNA repair were correlated with the alterations in Smad2 phosphorylation status and Nkx2.1 expression levels, which has been considered as the lung cancer initiation gene. Methods : 140 nickel smelters and 140 age-matched administrative officers were randomly stratified by service length from Jinchang Cohort. Canonical regression, χ 2 test, Spearman correlation etc. were used to evaluate the association among service length, MDA, 8-OHdG, hOGG1, PARP, pSmad2, and Nkx2.1. Results : The concentrations of MDA, PARP, pSmad2, and Nkx2.1 significantly increased. Nkx2.1 ( r s = 0.312, p < 0.001) and Smad2 phosphorylation levels ( r s = 0.232, p = 0.006) were positively correlated with the employment length in nickel smelters, which was not observed in the administrative officer group. Also, elevation of Nkx2.1 expression was positively correlated with service length, 8-OHdG, PARP, hOGG1 and pSmad2 levels in nickel smelters. Conclusions : Occupational nickel exposure could increase the expression of Nkx2.1 and pSmad2, which correlated with the nickel-induced oxidative damage and DNA repair change.

Suggested Citation

  • Zhiyuan Cheng & Ning Cheng & Dian Shi & Xiaoyu Ren & Ting Gan & Yana Bai & Kehu Yang, 2019. "The Relationship between Nkx2.1 and DNA Oxidative Damage Repair in Nickel Smelting Workers: Jinchang Cohort Study," IJERPH, MDPI, vol. 16(1), pages 1-15, January.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:1:p:120-:d:194937
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    References listed on IDEAS

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    1. Hongbin Ji & Matthew R. Ramsey & D. Neil Hayes & Cheng Fan & Kate McNamara & Piotr Kozlowski & Chad Torrice & Michael C. Wu & Takeshi Shimamura & Samanthi A. Perera & Mei-Chih Liang & Dongpo Cai & Geo, 2007. "LKB1 modulates lung cancer differentiation and metastasis," Nature, Nature, vol. 448(7155), pages 807-810, August.
    2. Monte M. Winslow & Talya L. Dayton & Roel G. W. Verhaak & Caroline Kim-Kiselak & Eric L. Snyder & David M. Feldser & Diana D. Hubbard & Michel J. DuPage & Charles A. Whittaker & Sebastian Hoersch & St, 2011. "Suppression of lung adenocarcinoma progression by Nkx2-1," Nature, Nature, vol. 473(7345), pages 101-104, May.
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