IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v448y2007i7154d10.1038_nature06029.html
   My bibliography  Save this article

A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord

Author

Listed:
  • Yan-Gang Sun

    (Department of Anesthesiology,)

  • Zhou-Feng Chen

    (Department of Anesthesiology,
    Department of Molecular Biology and Pharmacology,
    Washington University School of Medicine Pain Center, St Louis, Missouri 63110, USA)

Abstract

Technical itch The unpleasant sense of itching, or pruritus, is well known, but its neurobiological basis has remained elusive. Now the first molecular player in the 'itch pathway' has been identified. Historically, itch has been regarded as a less intense variant of the pain sensation. But work with knockout mice shows that the 'gastrin-releasing peptide receptor' is important for communication of itchy, but not painful, stimuli to the central nervous system. This receptor could therefore be a target for the development of antipruritic drugs that do not affect pain signalling.

Suggested Citation

  • Yan-Gang Sun & Zhou-Feng Chen, 2007. "A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord," Nature, Nature, vol. 448(7154), pages 700-703, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7154:d:10.1038_nature06029
    DOI: 10.1038/nature06029
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06029
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06029?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kensho Kanehisa & Keisuke Koga & Sho Maejima & Yuto Shiraishi & Konatsu Asai & Miho Shiratori-Hayashi & Mei-Fang Xiao & Hirotaka Sakamoto & Paul F. Worley & Makoto Tsuda, 2022. "Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Peter Elliott & Max G’Sell & Lindsey M Snyder & Sarah E Ross & Valérie Ventura, 2017. "Automated acoustic detection of mouse scratching," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-16, July.
    3. Chan Kam Tim Michael & Tong Kwun Wah & Hiu Kim Yuen, 2018. "Chronic Itch-Scratch Behaviour is a Cognitive Phenomenon Mediated through Neuroendocrine Receptors," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 11(5), pages 8849-8854, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:448:y:2007:i:7154:d:10.1038_nature06029. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.