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New cell lines from mouse epiblast share defining features with human embryonic stem cells

Author

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  • Paul J. Tesar

    (Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mammalian Development Laboratory, University of Oxford, South Parks Road, Oxford OX1 3PS, UK)

  • Josh G. Chenoweth

    (Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Frances A. Brook

    (Mammalian Development Laboratory, University of Oxford, South Parks Road, Oxford OX1 3PS, UK)

  • Timothy J. Davies

    (Mammalian Development Laboratory, University of Oxford, South Parks Road, Oxford OX1 3PS, UK)

  • Edward P. Evans

    (Mammalian Development Laboratory, University of Oxford, South Parks Road, Oxford OX1 3PS, UK)

  • David L. Mack

    (Stem Cell Biology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Richard L. Gardner

    (Mammalian Development Laboratory, University of Oxford, South Parks Road, Oxford OX1 3PS, UK)

  • Ronald D. G. McKay

    (Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA)

Abstract

A new type of stem cell Human embryonic stem (ES) cells are potentially important in therapy because they are pluripotent, capable of differentiating into virtually any cell type given appropriate encouragement. One obstacle to progress in research on them has been the baffling differences between human and mouse ES cells. Now two groups working independently have created a new kind of pluripotent ES cell. Derived from mouse embryos after they implant in the wall of the uterus, these EpiSCs (epiblast stem cells) are distinct from 'classic' mouse ES cells and mirror key features of human ES cells. The discovery of EpiSCs should provide an important experimental model to accelerate the use of human ES cells in research and eventually perhaps, in therapy.

Suggested Citation

  • Paul J. Tesar & Josh G. Chenoweth & Frances A. Brook & Timothy J. Davies & Edward P. Evans & David L. Mack & Richard L. Gardner & Ronald D. G. McKay, 2007. "New cell lines from mouse epiblast share defining features with human embryonic stem cells," Nature, Nature, vol. 448(7150), pages 196-199, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7150:d:10.1038_nature05972
    DOI: 10.1038/nature05972
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    Citations

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    Cited by:

    1. Kory R Johnson & Barbara S Mallon & Yang C Fann & Kevin G Chen, 2021. "Multivariate meta-analysis reveals global transcriptomic signatures underlying distinct human naive-like pluripotent states," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-24, May.
    2. Raamesh Deshpande & Shikha Sharma & Catherine M Verfaillie & Wei-Shou Hu & Chad L Myers, 2010. "A Scalable Approach for Discovering Conserved Active Subnetworks across Species," PLOS Computational Biology, Public Library of Science, vol. 6(12), pages 1-18, December.
    3. Woranop Sukparangsi & Elena Morganti & Molly Lowndes & Hélène Mayeur & Melanie Weisser & Fella Hammachi & Hanna Peradziryi & Fabian Roske & Jurriaan Hölzenspies & Alessandra Livigni & Benoit Gilbert G, 2022. "Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    4. Anna Malkowska & Christopher Penfold & Sophie Bergmann & Thorsten E. Boroviak, 2022. "A hexa-species transcriptome atlas of mammalian embryogenesis delineates metabolic regulation across three different implantation modes," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    5. Siti Razila Abdul Razak & Kazuko Ueno & Naoya Takayama & Naoki Nariai & Masao Nagasaki & Rika Saito & Hideto Koso & Chen-Yi Lai & Miyako Murakami & Koichiro Tsuji & Tatsuo Michiue & Hiromitsu Nakauchi, 2013. "Profiling of MicroRNA in Human and Mouse ES and iPS Cells Reveals Overlapping but Distinct MicroRNA Expression Patterns," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-16, September.
    6. Milan Kumar Samanta & Srimonta Gayen & Clair Harris & Emily Maclary & Yumie Murata-Nakamura & Rebecca M. Malcore & Robert S. Porter & Patricia M. Garay & Christina N. Vallianatos & Paul B. Samollow & , 2022. "Activation of Xist by an evolutionarily conserved function of KDM5C demethylase," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. Andrea Lauria & Guohua Meng & Valentina Proserpio & Stefania Rapelli & Mara Maldotti & Isabelle Laurence Polignano & Francesca Anselmi & Danny Incarnato & Anna Krepelova & Daniela Donna & Chiara Levra, 2023. "DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    8. Marissa Cloutier & Surinder Kumar & Emily Buttigieg & Laura Keller & Brandon Lee & Aaron Williams & Sandra Mojica-Perez & Indri Erliandri & Andre Monteiro Da Rocha & Kenneth Cadigan & Gary D. Smith & , 2022. "Preventing erosion of X-chromosome inactivation in human embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    9. Francesco Panariello & Onelia Gagliano & Camilla Luni & Antonio Grimaldi & Silvia Angiolillo & Wei Qin & Anna Manfredi & Patrizia Annunziata & Shaked Slovin & Lorenzo Vaccaro & Sara Riccardo & Valenti, 2023. "Cellular population dynamics shape the route to human pluripotency," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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