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Energy-dependent regulation of cell structure by AMP-activated protein kinase

Author

Listed:
  • Jun Hee Lee

    (National Creative Research Initiatives Center for Cell Growth Regulation, and,
    Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Taejon 305-701, Korea)

  • Hyongjong Koh

    (National Creative Research Initiatives Center for Cell Growth Regulation, and,
    Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Taejon 305-701, Korea)

  • Myungjin Kim

    (National Creative Research Initiatives Center for Cell Growth Regulation, and,
    Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Taejon 305-701, Korea)

  • Yongsung Kim

    (National Creative Research Initiatives Center for Cell Growth Regulation, and,
    Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Taejon 305-701, Korea)

  • Soo Young Lee

    (National Creative Research Initiatives Center for Cell Growth Regulation, and,
    Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Taejon 305-701, Korea)

  • Roger E. Karess

    (Centre National de la Recherche Scientifique, Centre de Génétique Moléculaire, Avenue de la Terrasse, 91198 Gif sur Yvette, France)

  • Sang-Hee Lee

    (Korea Basic Science Institute, 52 Eoeun-Dong, Yusong-Gu, Taejon 305-333, Korea)

  • Minho Shong

    (and)

  • Jin-Man Kim

    (Chungnam National University School of Medicine, 640 Daesa-Dong, Chung-Gu, Taejon 301-721, Korea)

  • Jaeseob Kim

    (Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Taejon 305-701, Korea
    GenExel, 373-1 Kusong-Dong, Yusong-Gu, Taejon 305-701, Korea)

  • Jongkyeong Chung

    (National Creative Research Initiatives Center for Cell Growth Regulation, and,
    Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Taejon 305-701, Korea)

Abstract

AMP-activated protein kinase (AMPK) is important for mitosis and epithelial cell polarity and these effects are a result of direct phosphorylation of non-muscle myosin regulatory light chain by AMPK. This is the first study reporting AMPK deletion in an entire organism and highlights the physiological function of this kinase.

Suggested Citation

  • Jun Hee Lee & Hyongjong Koh & Myungjin Kim & Yongsung Kim & Soo Young Lee & Roger E. Karess & Sang-Hee Lee & Minho Shong & Jin-Man Kim & Jaeseob Kim & Jongkyeong Chung, 2007. "Energy-dependent regulation of cell structure by AMP-activated protein kinase," Nature, Nature, vol. 447(7147), pages 1017-1020, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7147:d:10.1038_nature05828
    DOI: 10.1038/nature05828
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    Cited by:

    1. Yaqiong Li & Zhipeng Niu & Jichao Yang & Xuke Yang & Yukun Chen & Yingying Li & Xiaohan Liang & Jingwen Zhang & Fuqiang Fan & Ping Wu & Chao Peng & Bang Shen, 2023. "Rapid metabolic reprogramming mediated by the AMP-activated protein kinase during the lytic cycle of Toxoplasma gondii," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Florent Peglion & Lavinia Capuana & Isabelle Perfettini & Laurent Boucontet & Ben Braithwaite & Emma Colucci-Guyon & Emie Quissac & Karin Forsberg-Nilsson & Flora Llense & Sandrine Etienne-Manneville, 2022. "PTEN inhibits AMPK to control collective migration," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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