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Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

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  • Rolf Thermann

    (European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

  • Matthias W. Hentze

    (European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

Abstract

Paths to gene silence Two studies this week report on gene silencing by microRNAs (miRNAs), the small RNAs that regulate messenger RNA stability and translation. Chendrimada et al. show that the three-molecule complex RISC, which is known to generate miRNAs, interacts with the MOV10 complex that includes the ribosome anti-association factor eIF6. This points to a role for eIF6 as an evolutionarily conserved mediator of miRNA-directed gene silencing. Rolf Thermann and Matthias Hentze find that the Drosophila miRNA miR2 blocks protein formation by producing large miRNA complexes that strongly resemble ribosomes. mRNAs locked into the resulting pseudo-polysome are effectively put out of action.

Suggested Citation

  • Rolf Thermann & Matthias W. Hentze, 2007. "Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation," Nature, Nature, vol. 447(7146), pages 875-878, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7146:d:10.1038_nature05878
    DOI: 10.1038/nature05878
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    Cited by:

    1. Yize Zhao & Matthias Chung & Brent A. Johnson & Carlos S. Moreno & Qi Long, 2016. "Hierarchical Feature Selection Incorporating Known and Novel Biological Information: Identifying Genomic Features Related to Prostate Cancer Recurrence," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(516), pages 1427-1439, October.

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