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RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Author

Listed:
  • Nicholas Yagoda

    (Fairchild Center, 1212 Amsterdam Avenue, MC 2406)

  • Moritz von Rechenberg

    (Prolexys Pharmaceuticals, 2150 West Dauntless Avenue, Salt Lake City, Utah 84116, USA)

  • Elma Zaganjor

    (Fairchild Center, 1212 Amsterdam Avenue, MC 2406)

  • Andras J. Bauer

    (Fairchild Center, 1212 Amsterdam Avenue, MC 2406)

  • Wan Seok Yang

    (Fairchild Center, 1212 Amsterdam Avenue, MC 2406)

  • Daniel J. Fridman

    (Fairchild Center, 1212 Amsterdam Avenue, MC 2406)

  • Adam J. Wolpaw

    (Fairchild Center, 1212 Amsterdam Avenue, MC 2406)

  • Inese Smukste

    (Fairchild Center, 1212 Amsterdam Avenue, MC 2406)

  • John M. Peltier

    (Prolexys Pharmaceuticals, 2150 West Dauntless Avenue, Salt Lake City, Utah 84116, USA)

  • J. Jay Boniface

    (Prolexys Pharmaceuticals, 2150 West Dauntless Avenue, Salt Lake City, Utah 84116, USA)

  • Richard Smith

    (Center for Children, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA)

  • Stephen L. Lessnick

    (Center for Children, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA
    Division of Pediatric Hematology/Oncology, the Department of Oncological Sciences)

  • Sudhir Sahasrabudhe

    (Prolexys Pharmaceuticals, 2150 West Dauntless Avenue, Salt Lake City, Utah 84116, USA)

  • Brent R. Stockwell

    (Fairchild Center, 1212 Amsterdam Avenue, MC 2406
    Columbia University, New York, New York 10027, USA)

Abstract

Mitochondrial target A screen for small molecules that kill tumour cells with mutations in the oncogene HRAS has yielded a compound called erastin. Erastin treatment of cells expressing oncogenic RAS leads to cell death via an oxidative, non-apoptotic mechanism. Erastin acts via mitochondrial voltage-dependent anion channels, a novel target that could lead to new genotype-selective anticancer drugs.

Suggested Citation

  • Nicholas Yagoda & Moritz von Rechenberg & Elma Zaganjor & Andras J. Bauer & Wan Seok Yang & Daniel J. Fridman & Adam J. Wolpaw & Inese Smukste & John M. Peltier & J. Jay Boniface & Richard Smith & Ste, 2007. "RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels," Nature, Nature, vol. 447(7146), pages 865-869, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7146:d:10.1038_nature05859
    DOI: 10.1038/nature05859
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    Cited by:

    1. Yutian Zou & Shaoquan Zheng & Xinhua Xie & Feng Ye & Xiaoqian Hu & Zhi Tian & Shu-Mei Yan & Lu Yang & Yanan Kong & Yuhui Tang & Wenwen Tian & Jindong Xie & Xinpei Deng & Yan Zeng & Zhe-Sheng Chen & Ha, 2022. "N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Huirui Wang & Xiaona You & Jingcheng Wang & Xinyi Chen & Yinghui Gao & Mengmeng Wang & Wenru Zhang & Jiaozhen Zhang & Yang Yu & Bo Han & Mei Qi & Xiaohui Liu & Hongxiang Lou & Ting Dong, 2024. "MFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Nathan P. Ward & Sang Jun Yoon & Tyce Flynn & Amanda M. Sherwood & Maddison A. Olley & Juliana Madej & Gina M. DeNicola, 2024. "Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Jun-Yan Li & Yin Zhao & Sha Gong & Miao-Miao Wang & Xu Liu & Qing-Mei He & Ying-Qin Li & Sheng-Yan Huang & Han Qiao & Xi-Rong Tan & Ming-Liang Ye & Xun-Hua Zhu & Shi-Wei He & Qian Li & Ye-Lin Liang & , 2023. "TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Caterina Bartolacci & Cristina Andreani & Gonçalo Vale & Stefano Berto & Margherita Melegari & Anna Colleen Crouch & Dodge L. Baluya & George Kemble & Kurt Hodges & Jacqueline Starrett & Katerina Poli, 2022. "Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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