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8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

Author

Listed:
  • Giovanni Maga

    (Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy
    Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland)

  • Giuseppe Villani

    (Institute de Pharmacologie et de Biologie Structurale, IPBS-CNRS, Centre National de la Recherche Scientifique, Route de Narbonne 205, 31077 Toulouse, France)

  • Emmanuele Crespan

    (Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy)

  • Ursula Wimmer

    (Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland)

  • Elena Ferrari

    (Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland)

  • Barbara Bertocci

    (Institute National Français de Recherche Médicale, Université Paris Descartes, Faculté de Médecine René Descartes, Site Necker-Enfants Malades, 156 rue de Vaugirard 75730 Paris, Cedex 15, France)

  • Ulrich Hübscher

    (Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland)

Abstract

The replication accessory proteins PCNA and RPA are unexpectedly able to stimulate the activity of some of the polymerases that catalyse DNA synthesis. It is speculated that the ability of some polymerases to have their activity enhanced in this way sets up a hierarchy of polymerase utilization at DNA lesions.

Suggested Citation

  • Giovanni Maga & Giuseppe Villani & Emmanuele Crespan & Ursula Wimmer & Elena Ferrari & Barbara Bertocci & Ulrich Hübscher, 2007. "8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins," Nature, Nature, vol. 447(7144), pages 606-608, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7144:d:10.1038_nature05843
    DOI: 10.1038/nature05843
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    Cited by:

    1. Pierre Dupuy & Shreya Ghosh & Oyindamola Adefisayo & John Buglino & Stewart Shuman & Michael S. Glickman, 2022. "Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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