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The complex language of chromatin regulation during transcription

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  • Shelley L. Berger

    (The Wistar Institute, 3601 Spruce Street, Room 201, Philadelphia, Pennsylvania 19104, USA.)

Abstract

An important development in understanding the influence of chromatin on gene regulation has been the finding that DNA methylation and histone post-translational modifications lead to the recruitment of protein complexes that regulate transcription. Early interpretations of this phenomenon involved gene regulation reflecting predictive activating or repressing types of modification. However, further exploration reveals that transcription occurs against a backdrop of mixtures of complex modifications, which probably have several roles. Although such modifications were initially thought to be a simple code, a more likely model is of a sophisticated, nuanced chromatin 'language' in which different combinations of basic building blocks yield dynamic functional outcomes.

Suggested Citation

  • Shelley L. Berger, 2007. "The complex language of chromatin regulation during transcription," Nature, Nature, vol. 447(7143), pages 407-412, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7143:d:10.1038_nature05915
    DOI: 10.1038/nature05915
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    Cited by:

    1. Tsionas, Efthymios G. & Assaf, A. George & Matousek, Roman, 2015. "Dynamic technical and allocative efficiencies in European banking," Journal of Banking & Finance, Elsevier, vol. 52(C), pages 130-139.
    2. Ke Chen & Li Wang & Zishuo Yu & Jiali Yu & Yulei Ren & Qianmin Wang & Yanhui Xu, 2024. "Structure of the human TIP60 complex," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Dario Siniscalco & Alessandra Cirillo & James Jeffrey Bradstreet & Nicola Antonucci, 2013. "Epigenetic Findings in Autism: New Perspectives for Therapy," IJERPH, MDPI, vol. 10(9), pages 1-13, September.
    4. Yu Tao & Yuan Zhang & Xiaohong Jin & Nan Hua & Hong Liu & Renfei Qi & Zitong Huang & Yufang Sun & Dongsheng Jiang & Terrance P. Snutch & Xinghong Jiang & Jin Tao, 2023. "Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    5. A. R. Khan & S. M. Shah & M. Irshad, 2015. "Immediate and Transgenerational Regulation of Plant Stress Response through DNA Methylation," Journal of Agricultural Science, Canadian Center of Science and Education, vol. 7(4), pages 144-144, March.
    6. Yunfan Li & Dan Zhang & Mouxing Yang & Dezhong Peng & Jun Yu & Yu Liu & Jiancheng Lv & Lu Chen & Xi Peng, 2023. "scBridge embraces cell heterogeneity in single-cell RNA-seq and ATAC-seq data integration," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    7. Chao He & Siteng Bi & Yuqi Li & Chengxiang Song & Heping Zhang & Xintong Xu & Qiang Li & Sulaiman Saeed & Wei Chen & Chunjie Zhao & Caixia Lan & Handong Su & Hailiang Mao & Wenhao Yan, 2024. "Dynamic atlas of histone modifications and gene regulatory networks in endosperm of bread wheat," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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