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A positive feedback mechanism governs the polarity and motion of motile cilia

Author

Listed:
  • Brian Mitchell

    (The Salk Institute for Biological Studies, La Jolla, California 92186, USA)

  • Richard Jacobs

    (The Salk Institute for Biological Studies, La Jolla, California 92186, USA
    Howard Hughes Medical Institute, USA)

  • Julie Li

    (University of California San Diego, La Jolla, California 92093, USA)

  • Shu Chien

    (University of California San Diego, La Jolla, California 92093, USA)

  • Chris Kintner

    (The Salk Institute for Biological Studies, La Jolla, California 92186, USA)

Abstract

On cells with motile cilia, cilia not only generate flow along a specific axis, but are involved in sensing and responding to that flow in a way that influences cell polarity. This model suggests a new paradigm for how polarity can be generated in a developing tissue, which will be of general interest to all developmental biologists.

Suggested Citation

  • Brian Mitchell & Richard Jacobs & Julie Li & Shu Chien & Chris Kintner, 2007. "A positive feedback mechanism governs the polarity and motion of motile cilia," Nature, Nature, vol. 447(7140), pages 97-101, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7140:d:10.1038_nature05771
    DOI: 10.1038/nature05771
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    Cited by:

    1. Takayuki Yasunaga & Johannes Wiegel & Max D. Bergen & Martin Helmstädter & Daniel Epting & Andrea Paolini & Özgün Çiçek & Gerald Radziwill & Christina Engel & Thomas Brox & Olaf Ronneberger & Peter Wa, 2022. "Microridge-like structures anchor motile cilia," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Toshinori Namba & Shuji Ishihara, 2020. "Cytoskeleton polarity is essential in determining orientational order in basal bodies of multi-ciliated cells," PLOS Computational Biology, Public Library of Science, vol. 16(2), pages 1-18, February.

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