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Weighing of biomolecules, single cells and single nanoparticles in fluid

Author

Listed:
  • Thomas P. Burg

    (Department of Biological Engineering,)

  • Michel Godin

    (Department of Biological Engineering,)

  • Scott M. Knudsen

    (Department of Biological Engineering,)

  • Wenjiang Shen

    (Innovative Micro Technology, Santa Barbara, California 93117, USA)

  • Greg Carlson

    (Innovative Micro Technology, Santa Barbara, California 93117, USA)

  • John S. Foster

    (Innovative Micro Technology, Santa Barbara, California 93117, USA)

  • Ken Babcock

    (Innovative Micro Technology, Santa Barbara, California 93117, USA
    Affinity Biosensors, Santa Barbara, California 93117, USA)

  • Scott R. Manalis

    (Department of Biological Engineering,
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

Abstract

Nanobalances: weight for it Nanoscale mechanical resonators can be used to measure the mass of particles with extraordinarily high resolution down to the zeptogram scale — that's multiples of 10−21 grams. Such astonishing resolution has not been possible in many practical applications such as medical diagnostics or environmental monitoring, where the presence of fluids dampens the mechanical vibrations that make the system work. Now a team from MIT and the Santa Barbara labs of Innovative Micro Technology and Affinity Biosensors has devised an ingenious way around this problem by placing the fluid inside the resonator. Their vacuum-packaged resonator, with the solution with particles of interest held in microfluidic channels, can weigh single nanoparticles and bacteria at subfemtogram (10−15 g) resolution.

Suggested Citation

  • Thomas P. Burg & Michel Godin & Scott M. Knudsen & Wenjiang Shen & Greg Carlson & John S. Foster & Ken Babcock & Scott R. Manalis, 2007. "Weighing of biomolecules, single cells and single nanoparticles in fluid," Nature, Nature, vol. 446(7139), pages 1066-1069, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7139:d:10.1038_nature05741
    DOI: 10.1038/nature05741
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    Cited by:

    1. Stefano Stassi & Ido Cooperstein & Mauro Tortello & Candido Fabrizio Pirri & Shlomo Magdassi & Carlo Ricciardi, 2021. "Reaching silicon-based NEMS performances with 3D printed nanomechanical resonators," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    2. Andreas P. Cuny & K. Tanuj Sapra & David Martinez-Martin & Gotthold Fläschner & Jonathan D. Adams & Sascha Martin & Christoph Gerber & Fabian Rudolf & Daniel J. Müller, 2022. "High-resolution mass measurements of single budding yeast reveal linear growth segments," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Hosseini-Ara, Reza & Mokhtarian, Ali & Karamrezaei, Amir Hossein & Toghraie, Davood, 2022. "Computational analysis of high precision nano-sensors for diagnosis of viruses: Effects of partial antibody layer," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 192(C), pages 384-398.

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